Cisplatin binding to human serum albumin: a structural study

被引：109
|
作者：
Ferraro, Giarita [1 ]
Massai, Lara [2 ]
Messori, Luigi [2 ]
Merlino, Antonello [1 ,3 ]
机构：
[1] Univ Naples Federico II, Dept Chem Sci, I-80126 Naples, Italy
[2] Univ Florence, Dept Chem, I-50019 Sesto Fiorentino, FI, Italy
[3] CNR Inst Biostruct & Bioimages, I-80126 Naples, Italy
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 46期
关键词：
X-RAY-STRUCTURE; SECONDARY STRUCTURE; MASS-SPECTROMETRY; CRYSTAL-STRUCTURE; IN-VITRO; PLATINUM; ANTICANCER; PROTEINS; ADDUCTS; CARBOPLATIN;
D O I：
10.1039/c5cc01751c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray crystallography and crystal structures of the cisplatin/HSA adduct were eventually solved for the first time. Structural data unambiguously prove that cisplatin mainly binds to His105 and Met329 side chains; additional binding sites are detected at His288, Met298, and Met548 and at His535, His67 and His247.
引用
收藏
页码：9436 / 9439
页数：4
相关论文
共 50 条
  • [21] Spectroscopic Study on Binding of Folic Acid to Human Serum Albumin
    Liu Hui-juan
    Li Peng
    Zhang Ya-dong
    Guo Cao
    Deng Jun-yuan
    Cai Jian-wei
    Liu Bo-li
    SPECTROSCOPY AND SPECTRAL ANALYSIS, 2009, 29 (07) : 1915 - 1919
  • [22] A molecular dynamics study on the binding of gemcitabine to human serum albumin
    Kharazian, B.
    Ahmad, A. A.
    Mabudi, A.
    JOURNAL OF MOLECULAR LIQUIDS, 2021, 337
  • [23] Binding of quercetin with human serum albumin: A critical spectroscopic study
    Sengupta, B
    Sengupta, PK
    BIOPOLYMERS, 2003, 72 (06) : 427 - 434
  • [24] Study of binding of colchicine to human serum albumin by Rayleigh light
    Masoomeh, Vahidzadeh
    Mohsen, Gharanfoli
    Jamshid, Chamani
    CLINICAL BIOCHEMISTRY, 2011, 44 (13) : S181 - S181
  • [25] Binding of trazodone hydrochloride with human serum albumin: A spectroscopic study
    Kandagal, P. B.
    Seetharamappa, J.
    Shaikh, S. M. T.
    Manjunatha, D. H.
    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 2007, 185 (2-3) : 239 - 244
  • [26] A Thermodynamic Study on the Binding of Human Serum Albumin with Lanthanum Ion
    Behbehani, Rezaei G.
    Divsalar, A.
    Saboury, A. A.
    Faridbod, F.
    Ganjali, M. R.
    CHINESE JOURNAL OF CHEMISTRY, 2010, 28 (02) : 159 - 163
  • [27] BINDING STUDY OF PHENYLBUTAZONE AND PIROXICAM TO HUMAN-SERUM ALBUMIN
    MOHAMED, HF
    ELBASSIOUNI, E
    SHAMSELDEEN, MA
    NASR, M
    ZEITOUN, R
    IRCS MEDICAL SCIENCE-BIOCHEMISTRY, 1986, 14 (01): : 29 - 30
  • [28] SPECTROSCOPIC STUDY ON BINDING OF FRACCETAIN TO HUMAN-SERUM ALBUMIN
    ZHAMYANSUREN, D
    STUDIA BIOPHYSICA, 1988, 128 (01): : 37 - 43
  • [29] QSPR Study on the Binding Constants of Coumarins and Human Serum Albumin
    Li, Mei-Ping
    Zhang, Sheng-Wan
    ASIAN JOURNAL OF CHEMISTRY, 2013, 25 (17) : 9643 - 9646
  • [30] Resveratrol binding to human serum albumin
    N'soukpoe-Kossi, C. N.
    St-Louis, C.
    Beauregard, M.
    Subirade, M.
    Carpentier, R.
    Hotchandani, S.
    Tajmir-Riahi, H. A.
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2006, 24 (03): : 277 - 283
12345