Cisplatin binding to human serum albumin: a structural study

被引：109

作者：

Ferraro, Giarita ^{[1
]}

Massai, Lara ^{[2
]}

Messori, Luigi ^{[2
]}

Merlino, Antonello ^{[1
,3
]}

机构：

[1] Univ Naples Federico II, Dept Chem Sci, I-80126 Naples, Italy

[2] Univ Florence, Dept Chem, I-50019 Sesto Fiorentino, FI, Italy

[3] CNR Inst Biostruct & Bioimages, I-80126 Naples, Italy

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 46期

关键词：

X-RAY-STRUCTURE; SECONDARY STRUCTURE; MASS-SPECTROMETRY; CRYSTAL-STRUCTURE; IN-VITRO; PLATINUM; ANTICANCER; PROTEINS; ADDUCTS; CARBOPLATIN;

D O I：

10.1039/c5cc01751c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray crystallography and crystal structures of the cisplatin/HSA adduct were eventually solved for the first time. Structural data unambiguously prove that cisplatin mainly binds to His105 and Met329 side chains; additional binding sites are detected at His288, Met298, and Met548 and at His535, His67 and His247.

引用

页码：9436 / 9439

页数：4

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