Cisplatin binding to human serum albumin: a structural study

被引：109
|
作者：
Ferraro, Giarita [1 ]
Massai, Lara [2 ]
Messori, Luigi [2 ]
Merlino, Antonello [1 ,3 ]
机构：
[1] Univ Naples Federico II, Dept Chem Sci, I-80126 Naples, Italy
[2] Univ Florence, Dept Chem, I-50019 Sesto Fiorentino, FI, Italy
[3] CNR Inst Biostruct & Bioimages, I-80126 Naples, Italy
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 46期
关键词：
X-RAY-STRUCTURE; SECONDARY STRUCTURE; MASS-SPECTROMETRY; CRYSTAL-STRUCTURE; IN-VITRO; PLATINUM; ANTICANCER; PROTEINS; ADDUCTS; CARBOPLATIN;
D O I：
10.1039/c5cc01751c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray crystallography and crystal structures of the cisplatin/HSA adduct were eventually solved for the first time. Structural data unambiguously prove that cisplatin mainly binds to His105 and Met329 side chains; additional binding sites are detected at His288, Met298, and Met548 and at His535, His67 and His247.
引用
收藏
页码：9436 / 9439
页数：4
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