Enhanced Two-Photon Singlet Oxygen Generation by Photosensitizer-Doped Conjugated Polymer Nanoparticles

被引：84

作者：

Shen, Xiaoqin ^{[1
]}

He, Fang

Wu, Jihong ^{[1
]}

Xu, Guo Qin ^{[1
]}

Yao, Shao Q. ^{[1
]}

Xu, Qing-Hua ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, 3 Sci Dr 3, Singapore 117543, Singapore

来源：

LANGMUIR | 2011年 / 27卷 / 05期

关键词：

RESONANCE ENERGY-TRANSFER; MODIFIED SILICA NANOPARTICLES; PHOTODYNAMIC THERAPY; DNA DETECTION; FLUORESCENCE; PORPHYRIN; ABSORPTION; SENSORS; CANCER; POLY(FLUORENYLENEETHYNYLENE)S;

D O I：

10.1021/la104722q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have prepared photosensitizer-doped conjugated polymer nanoparticles by using a reprecipitation method. The conjugated polymer, poly[9,9-dibromohexylfluorene-2,7-ylenethylene-alt-1,4-(2,5-dimethoxy)phenylene] (PFEMO), was used as the host matrix to disperse tetraphenylporphyrin (TPP). These TPP-doped PFEMO nanoparticles are stable and have a uniform size of similar to 50 nm. Efficient intraparticle energy transfer from PFEMO to TPP has been observed. The TPP emission of the nanoparticles was found to be enhanced by 21-fold by PFEMO under two-photon excitation. Enhanced two-photon excitation singlet oxygen generation efficiency in the TPP-doped PFEMO nanoparticles has been demonstrated. Our results suggest that these photosensitizer-doped conjugated polymer nanoparticles can act as novel photosensitizing agents for two-photon photodynamic therapy and related applications.

引用

页码：1739 / 1744

页数：6

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