Enhanced Two-Photon Singlet Oxygen Generation by Photosensitizer-Doped Conjugated Polymer Nanoparticles

被引：84
|
作者：
Shen, Xiaoqin [1 ]
He, Fang
Wu, Jihong [1 ]
Xu, Guo Qin [1 ]
Yao, Shao Q. [1 ]
Xu, Qing-Hua [1 ]
机构：
[1] Natl Univ Singapore, Dept Chem, 3 Sci Dr 3, Singapore 117543, Singapore
来源：
LANGMUIR | 2011年 / 27卷 / 05期
关键词：
RESONANCE ENERGY-TRANSFER; MODIFIED SILICA NANOPARTICLES; PHOTODYNAMIC THERAPY; DNA DETECTION; FLUORESCENCE; PORPHYRIN; ABSORPTION; SENSORS; CANCER; POLY(FLUORENYLENEETHYNYLENE)S;
D O I：
10.1021/la104722q
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We have prepared photosensitizer-doped conjugated polymer nanoparticles by using a reprecipitation method. The conjugated polymer, poly[9,9-dibromohexylfluorene-2,7-ylenethylene-alt-1,4-(2,5-dimethoxy)phenylene] (PFEMO), was used as the host matrix to disperse tetraphenylporphyrin (TPP). These TPP-doped PFEMO nanoparticles are stable and have a uniform size of similar to 50 nm. Efficient intraparticle energy transfer from PFEMO to TPP has been observed. The TPP emission of the nanoparticles was found to be enhanced by 21-fold by PFEMO under two-photon excitation. Enhanced two-photon excitation singlet oxygen generation efficiency in the TPP-doped PFEMO nanoparticles has been demonstrated. Our results suggest that these photosensitizer-doped conjugated polymer nanoparticles can act as novel photosensitizing agents for two-photon photodynamic therapy and related applications.
引用
收藏
页码：1739 / 1744
页数：6
相关论文
共 50 条
  • [21] Polyfluorene based conjugated polymer nanoparticles for two-photon live cell imaging
    Shuang Li
    Xiao-Fang Jiang
    Qing-Hua Xu
    Science China Chemistry, 2018, 61 : 88 - 96
  • [22] Polyfluorene based conjugated polymer nanoparticles for two-photon live cell imaging
    Shuang Li
    XiaoFang Jiang
    QingHua Xu
    Science China(Chemistry), 2018, 61 (01) : 88 - 96
  • [23] Polyfluorene based conjugated polymer nanoparticles for two-photon live cell imaging
    Li, Shuang
    Jiang, Xiao-Fang
    Xu, Qing-Hua
    SCIENCE CHINA-CHEMISTRY, 2018, 61 (01) : 88 - 96
  • [24] Conjugated Polymer Nanoparticles for Two-Photon Imaging of Endothelial Cells in a Tissue Model
    Rahim, Nur Aida Abdul
    McDaniel, William
    Bardon, Kevin
    Srinivasan, Shalini
    Vickerman, Vernella
    So, Peter T. C.
    Moon, Joong Ho
    ADVANCED MATERIALS, 2009, 21 (34) : 3492 - +
  • [25] Polyfluorene based conjugated polymer nanoparticles for two-photon live cell imaging
    Shuang Li
    Xiao-Fang Jiang
    Qing-Hua Xu
    Science China(Chemistry) , 2018, (01) : 88 - 96
  • [26] Two-photon photosensitized production of singlet oxygen in water
    Frederiksen, PK
    McIlroy, SP
    Nielsen, CB
    Nikolajsen, L
    Skovsen, E
    Jorgensen, M
    Mikkelsen, KV
    Ogilby, PR
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (01) : 255 - 269
  • [27] Enhanced Two-Photon Emission in Coupled Metal Nanoparticles Induced by Conjugated Polymers
    Guan, Zhenping
    Polavarapu, Lakshminarayana
    Xu, Qing-Hua
    LANGMUIR, 2010, 26 (23) : 18020 - 18023
  • [28] Two-Photon Triplet Photosensitizers for Production of Singlet Oxygen
    Li Hongru
    Xie Ting
    Hu Nuedan
    Yang Liufeng
    Zhang Shengtao
    Gao Fang
    PROGRESS IN CHEMISTRY, 2009, 21 (7-8) : 1398 - 1407
  • [29] Efficient Singlet Oxygen Generation in Metal Nanoclusters for Two-Photon Photodynamic Therapy Applications
    Ho-Wu, Rosina
    Yau, Sung Hei
    Goodson, Theodore, III
    JOURNAL OF PHYSICAL CHEMISTRY B, 2017, 121 (43): : 10073 - 10080
  • [30] Singlet oxygen generation by two-photon excitation of porphyrin derivatives having two-photon-absorbing benzothiadiazole chromophores
    Ishi-i, Tsutomu
    Taguri, Yoshiki
    Kato, Shin-ichiro
    Shigeiwa, Motoyuki
    Gorohmaru, Hideki
    Maeda, Shuuichi
    Mataka, Shuntaro
    JOURNAL OF MATERIALS CHEMISTRY, 2007, 17 (31) : 3341 - 3346
12345