Recent progress in rational drug design of neuraminidase inhibitors

被引：30

作者：

Liu, Yu ^{[1
]}

Zhang, Jie ^{[1
]}

Xu, Wenfang ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Jinan 250012, ShanDong, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2007年 / 14卷 / 27期

关键词：

influenza virus; neuraminidase; neuraminidase inhibitor; pharmacophore model; antiviral agent; INFLUENZA-VIRUS NEURAMINIDASE; BEARING 4-GUANIDINO-NEU5AC2EN DERIVATIVES; POTENT ANTIINFLUENZA ACTIVITY; H5N1 AVIAN INFLUENZA; SIALIC-ACID ANALOGS; BENZOIC-ACID; STRUCTURAL-ANALYSIS; HIGHLY POTENT; ACTIVE-SITE; A VIRUSES;

D O I：

10.2174/092986707782360024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuraminidase is a major glycoprotein of influenza virus which is essential for viral infection and offers a potential target for antiviral drug development. Rational drug design of NA inhibitors is now in the clinic and these molecules are effective and safe for the treatment of influenza. Recently, research of structure-based NA inhibitors is becoming an interesting field, leading to a breakthrough in the control of influenza. Here we review the progress in the rational drug design of NA inhibitors in recent years.

引用

页码：2872 / 2891

页数：20

共 50 条

[41] Rational drug design
Mandal, Soma
Moudgil, Mee'nal
Mandal, Sanat K.
EUROPEAN JOURNAL OF PHARMACOLOGY, 2009, 625 (1-3) : 90 - 100
[42] Design and synthesis of benzoic acid derivatives as influenza neuraminidase inhibitors using structure-based drug design
Chand, P
Babu, YS
Bantia, S
Chu, NM
Cole, LB
Kotian, PL
Laver, WG
Montgomery, JA
Pathak, VP
Petty, SL
Shrout, DP
Walsh, DA
Walsh, GW
JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (25) : 4030 - 4052
[43] Rational drug design
Häyry, P
TRANSPLANT IMMUNOLOGY, 2002, 9 (2-4) : 201 - 201
[44] Progress of Computer-Aided Drug Design (CADD) of Proteasome Inhibitors
Lei, Meng
Liu, Yunde
Zhu, Yongqiang
Liu, Zhenming
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2011, 11 (23) : 2931 - 2944
[45] Recent Advances in the Rational Drug Design Based on Multi-target Ligands
Yang, Ting
Sui, Xin
Yu, Bing
Shen, Youqing
Cong, Hailin
CURRENT MEDICINAL CHEMISTRY, 2020, 27 (28) : 4720 - 4740
[46] Rational Drug Design Approach of Receptor Tyrosine Kinase Type III Inhibitors
Kim, Cheolhee
Kim, Eunae
CURRENT MEDICINAL CHEMISTRY, 2019, 26 (42) : 7623 - 7640
[47] Endothelin precursor isoforms: Structural basis for rational drug design of ECE inhibitors
Cronin, N
Peto, H
Wallace, BA
PEPTIDES FOR THE NEW MILLENNIUM, 2000, : 511 - 512
[48] CURRENT PROGRESS IN STRUCTURE-BASED RATIONAL DRUG DESIGN MARKS A NEW MINDSET IN DRUG DISCOVERY
Lounnas, Valere
Ritschel, Tina
Kelder, Jan
McGuire, Ross
Bywater, Robert P.
Foloppe, Nicolas
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2013, 5 (06):
[49] Recent progress in drug delivery
Chong Li
Jiancheng Wang
Yiguang Wang
Huile Gao
Gang Wei
Yongzhuo Huang
Haijun Yu
Yong Gan
Yongjun Wang
Lin Mei
Huabing Chen
Haiyan Hu
Zhiping Zhang
Yiguang Jin
Acta Pharmaceutica Sinica B, 2019, 9 (06) : 1145 - 1162
[50] Recent progress in drug delivery
Li, Chong
Wang, Jiancheng
Wang, Yiguang
Gao, Huile
Wei, Gang
Huang, Yongzhuo
Yu, Haijun
Gan, Yong
Wang, Yongjun
Mei, Lin
Chen, Huabing
Hu, Haiyan
Zhang, Zhiping
Jin, Yiguang
ACTA PHARMACEUTICA SINICA B, 2019, 9 (06) : 1145 - 1162

← 1 2 3 4 5 →