Recent progress in rational drug design of neuraminidase inhibitors

被引：30

作者：

Liu, Yu ^{[1
]}

Zhang, Jie ^{[1
]}

Xu, Wenfang ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Jinan 250012, ShanDong, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2007年 / 14卷 / 27期

关键词：

influenza virus; neuraminidase; neuraminidase inhibitor; pharmacophore model; antiviral agent; INFLUENZA-VIRUS NEURAMINIDASE; BEARING 4-GUANIDINO-NEU5AC2EN DERIVATIVES; POTENT ANTIINFLUENZA ACTIVITY; H5N1 AVIAN INFLUENZA; SIALIC-ACID ANALOGS; BENZOIC-ACID; STRUCTURAL-ANALYSIS; HIGHLY POTENT; ACTIVE-SITE; A VIRUSES;

D O I：

10.2174/092986707782360024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuraminidase is a major glycoprotein of influenza virus which is essential for viral infection and offers a potential target for antiviral drug development. Rational drug design of NA inhibitors is now in the clinic and these molecules are effective and safe for the treatment of influenza. Recently, research of structure-based NA inhibitors is becoming an interesting field, leading to a breakthrough in the control of influenza. Here we review the progress in the rational drug design of NA inhibitors in recent years.

引用

页码：2872 / 2891

页数：20

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