Recent progress in rational drug design of neuraminidase inhibitors

被引：30

作者：

Liu, Yu ^{[1
]}

Zhang, Jie ^{[1
]}

Xu, Wenfang ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Jinan 250012, ShanDong, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2007年 / 14卷 / 27期

关键词：

influenza virus; neuraminidase; neuraminidase inhibitor; pharmacophore model; antiviral agent; INFLUENZA-VIRUS NEURAMINIDASE; BEARING 4-GUANIDINO-NEU5AC2EN DERIVATIVES; POTENT ANTIINFLUENZA ACTIVITY; H5N1 AVIAN INFLUENZA; SIALIC-ACID ANALOGS; BENZOIC-ACID; STRUCTURAL-ANALYSIS; HIGHLY POTENT; ACTIVE-SITE; A VIRUSES;

D O I：

10.2174/092986707782360024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuraminidase is a major glycoprotein of influenza virus which is essential for viral infection and offers a potential target for antiviral drug development. Rational drug design of NA inhibitors is now in the clinic and these molecules are effective and safe for the treatment of influenza. Recently, research of structure-based NA inhibitors is becoming an interesting field, leading to a breakthrough in the control of influenza. Here we review the progress in the rational drug design of NA inhibitors in recent years.

引用

页码：2872 / 2891

页数：20

共 50 条

[21] Recent progress in the machine learning-assisted rational design of alloys
Huadong Fu
Hongtao Zhang
Changsheng Wang
Wei Yong
Jianxin Xie
International Journal of Minerals, Metallurgy and Materials, 2022, 29 : 635 - 644
[22] Recent progress and rational design of perovskite-based chemosensors: A review
Maulida, Pramitha Yuniar Diah
Subagyo, Riki
Hartati, Sri
Jovita, Stella
Zulfa, Liyana Labiba
Hakim, Hanan
Birowosuto, Muhammad Danang
Kusumawati, Yuly
Arramel
JOURNAL OF ALLOYS AND COMPOUNDS, 2023, 962
[23] Surface-Engineered Cancer Nanomedicine: Rational Design and Recent Progress
Ahmad, Javed
Ameeduzzafar
Ahmad, Mohammad Z.
Akhter, Habban
CURRENT PHARMACEUTICAL DESIGN, 2020, 26 (11) : 1181 - 1190
[24] Recent progress in the machine learning-assisted rational design of alloys
Huadong Fu
Hongtao Zhang
Changsheng Wang
Wei Yong
Jianxin Xie
InternationalJournalofMinerals,MetallurgyandMaterials, 2022, (04) : 635 - 644
[25] Recent Progress in the Rational Design of Biothiol-Responsive Fluorescent Probes
Xie, Wenzhi
Jiang, Jinyu
Shu, Dunji
Zhang, Yanjun
Yang, Sheng
Zhang, Kai
MOLECULES, 2023, 28 (10):
[26] Recent progress in the machine learning-assisted rational design of alloys
Fu, Huadong
Zhang, Hongtao
Wang, Changsheng
Yong, Wei
Xie, Jianxin
INTERNATIONAL JOURNAL OF MINERALS METALLURGY AND MATERIALS, 2022, 29 (04) : 635 - 644
[27] Recent advances in structure-based rational drug design
Gane, PJ
Dean, PM
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2000, 10 (04) : 401 - 404
[28] Rational drug screening on neuraminidase (NA) inhibitors of influenza virus using support vector machine (SVM)
Liu, Ai-lin
Li, Chao
Du, Guan-hua
ACTA PHARMACOLOGICA SINICA, 2013, 34 : 45 - 45
[29] Recent progress in epoxy resins as corrosion inhibitors: design and performance
Dagdag, Omar
Haldhar, Rajesh
Kim, Seong-Cheol
Guo, Lei
El Gouri, M.
Berdimurodov, Elyor
Hamed, O.
Jodeh, S.
Akpan, Ekemini D.
Ebenso, Eno E.
JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY, 2023, 37 (06) : 923 - 944
[30] Recent progress in rational design of fluorescent probes for Fe2+and bioapplication
Lu, Yao
Ruan, Guotong
Du, Wei
Li, Jie
Yang, Naidi
Wu, Qiong
Lu, Li
Zhang, Chengwu
Li, Lin
DYES AND PIGMENTS, 2021, 190

← 1 2 3 4 5 →