Alveolar Epithelial Type II Cells and Their Microenvironment in the Caveolin-1-Deficient Mouse

被引：7
|
作者：
Jung, Kristina [2 ]
Schlenz, Heike [2 ]
Krasteva, Gabriela [2 ]
Muehlfeld, Christian [1 ,2 ]
机构：
[1] Hannover Med Sch, Inst Funct & Appl Anat, D-30625 Hannover, Germany
[2] Univ Giessen, Inst Anat & Cell Biol, Giessen, Germany
来源：
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY | 2012年 / 295卷 / 02期
关键词：
caveolin-1; caveolae; Type II cells; electron microscopy; stereology; PULMONARY SURFACTANT SYSTEM; LUNG; EXPRESSION; CAVEOLAE; MICE;
D O I：
10.1002/ar.21543
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Caveolin-1 (Cav-1) is highly expressed in alveolar epithelial type I (AE1) and endothelial cells of the alveolar region of the lung. Interestingly, alveolar epithelial type II (AE2) cells that are progenitors of the AE1 cells do not express Cav-1. We investigated whether genetic Cav-1 deficiency alters the phenotype of AE2 cells and their microenvironment using stereology. Total number, mean volume, and subcellular composition of the AE2 cells were not altered in Cav-1-/- when compared with wild-type mice. The alveolar septa were thickened and contained a significantly greater volume of extracellular matrix. Thus, AE2 cells as progenitors of AE1 cells are not critically involved in the severe pulmonary phenotype in Cav-1-deficient mice. Anat Rec, 2012. (C) 2011 Wiley Periodicals, Inc.
引用
收藏
页码：196 / 200
页数：5
相关论文
共 50 条
  • [41] Upregulation of aldose reductase by homocysteine in type II alveolar epithelial cells
    Jiang, H
    Wang, XF
    Fang, L
    Tang, CS
    Zhu, Y
    Wang, X
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 337 (04) : 1084 - 1091
  • [42] Response of alveolar type II epithelial cells to mechanical stretch and lipopolysaccharide
    Ning, Qiao-Ming
    Wang, Xiang-Rui
    RESPIRATION, 2007, 74 (05) : 579 - 585
  • [43] Preservation of the Characteristics of the Cultured Human Type II Alveolar Epithelial Cells
    Kimiko Takahashi
    Masako Mitsui
    Kyoko Takeuchi
    Yasuhide Uwabe
    Katsuyuki Kobayashi
    Yoshio Sawasaki
    Takeshi Matsuoka
    Lung, 2004, 182 : 213 - 226
  • [44] TYPE-II ALVEOLAR EPITHELIAL-CELLS - CHEMICAL CHARACTERIZATION
    KIKKAWA, Y
    SMITH, F
    YONEDA, K
    SUZUKI, K
    AMERICAN REVIEW OF RESPIRATORY DISEASE, 1974, 109 (06): : 731 - 732
  • [45] MONOCROTALINE, TYPE-II ALVEOLAR EPITHELIAL-CELLS AND POLYAMINES
    HACKER, A
    LIPCHIK, R
    EFFROS, RM
    SEAVITTE, C
    REIN, D
    FASEB JOURNAL, 1992, 6 (04): : A1066 - A1066
  • [46] microRNA Expression Profile of Purified Alveolar Epithelial Type II Cells
    Dehmel, Stefan
    Weiss, Katharina J.
    El-Merhie, Natalia
    Callegari, Jens
    Konrad, Birte
    Mutze, Kathrin
    Eickelberg, Oliver
    Konigshoff, Melanie
    Krauss-Etschmann, Susanne
    GENES, 2022, 13 (08)
  • [47] AN OVINE PULMONARY TUMOR OF ALVEOLAR EPITHELIAL TYPE-II CELLS
    DALEFIELD, RR
    ALLEY, MR
    NEW ZEALAND VETERINARY JOURNAL, 1988, 36 (01) : 25 - 27
  • [48] Inflammation and ErbB receptors in murine alveolar epithelial type II cells
    Seitz, I
    Nassimi, N
    Dammann, O
    Dammann, C
    PEDIATRIC RESEARCH, 2004, 55 (04) : 88A - 88A
  • [49] Activation of type II alveolar epithelial cells during acute endotoxemia
    Sunil, VR
    Connor, AJ
    Guo, Y
    Laskin, JD
    Laskin, DL
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2002, 282 (04) : L872 - L880
  • [50] Lactate as substrate for mitochondrial respiration in alveolar epithelial type II cells
    Lottes, Robyn G.
    Newton, Danforth A.
    Spyropoulos, Demetri D.
    Baatz, John E.
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2015, 308 (09) : L953 - L961
12345