Alveolar Epithelial Type II Cells and Their Microenvironment in the Caveolin-1-Deficient Mouse

被引：7
|
作者：
Jung, Kristina [2 ]
Schlenz, Heike [2 ]
Krasteva, Gabriela [2 ]
Muehlfeld, Christian [1 ,2 ]
机构：
[1] Hannover Med Sch, Inst Funct & Appl Anat, D-30625 Hannover, Germany
[2] Univ Giessen, Inst Anat & Cell Biol, Giessen, Germany
来源：
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY | 2012年 / 295卷 / 02期
关键词：
caveolin-1; caveolae; Type II cells; electron microscopy; stereology; PULMONARY SURFACTANT SYSTEM; LUNG; EXPRESSION; CAVEOLAE; MICE;
D O I：
10.1002/ar.21543
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Caveolin-1 (Cav-1) is highly expressed in alveolar epithelial type I (AE1) and endothelial cells of the alveolar region of the lung. Interestingly, alveolar epithelial type II (AE2) cells that are progenitors of the AE1 cells do not express Cav-1. We investigated whether genetic Cav-1 deficiency alters the phenotype of AE2 cells and their microenvironment using stereology. Total number, mean volume, and subcellular composition of the AE2 cells were not altered in Cav-1-/- when compared with wild-type mice. The alveolar septa were thickened and contained a significantly greater volume of extracellular matrix. Thus, AE2 cells as progenitors of AE1 cells are not critically involved in the severe pulmonary phenotype in Cav-1-deficient mice. Anat Rec, 2012. (C) 2011 Wiley Periodicals, Inc.
引用
收藏
页码：196 / 200
页数：5
相关论文
共 50 条
  • [21] Impairment of Transforming Growth Factor β Signaling in Caveolin-1-deficient Hepatocytes ROLE IN LIVER REGENERATION
    Mayoral, Rafael
    Valverde, Angela M.
    Llorente Izquierdo, Cristina
    Gonzalez-Rodriguez, Agueda
    Bosca, Lisardo
    Martin-Sanz, Paloma
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (06) : 3633 - 3642
  • [22] Human alveolar epithelial type II cells in primary culture
    Mao, Pu
    Wu, Songling
    Li, Jianchun
    Fu, Wei
    He, Weiqun
    Liu, Xiaoqing
    Slutsky, Arthur S.
    Zhang, Haibo
    Li, Yimin
    PHYSIOLOGICAL REPORTS, 2015, 3 (02):
  • [23] Culture of human alveolar epithelial type II cells by sprouting
    Petra Khan
    Kleanthis Fytianos
    Luca Tamò
    Michael Roth
    Michael Tamm
    Thomas Geiser
    Amiq Gazdhar
    Katrin E Hostettler
    Respiratory Research, 19
  • [24] Culture of human alveolar epithelial type II cells by sprouting
    Khan, Petra
    Fytianos, Kleanthis
    Tamo, Luca
    Roth, Michael
    Tamm, Michael
    Geiser, Thomas
    Gazdhar, Amiq
    Hostettler, Katrin E.
    RESPIRATORY RESEARCH, 2018, 19
  • [25] ISOLATION AND METABOLISM OF ALVEOLAR EPITHELIAL TYPE-II CELLS
    PFLEGER, RC
    FEDERATION PROCEEDINGS, 1975, 34 (03) : 655 - 655
  • [26] microRNA profiling of murine alveolar epithelial type II cells
    Dehmel, Stefan
    Singer, Katharina
    Imker, Rabea
    Eickelberg, Oliver
    Koenigshoff, Melanie
    Krauss-Etschmann, Susanne
    EUROPEAN RESPIRATORY JOURNAL, 2012, 40
  • [27] E1A-induced immortalization of rat type II alveolar epithelial cells
    Pasternack, M
    Floerchinger, CS
    Hunninghake, GW
    EXPERIMENTAL LUNG RESEARCH, 1996, 22 (05) : 525 - 539
  • [28] mTORC1 Controls Cellular Senescence in Alveolar Epithelial Type II Cells
    Summer, R. S.
    Shaghaghi, H.
    Schriner, D.
    Hong, X.
    Sales, D.
    Desai, V.
    Bhushan, A.
    Ramirez, M.
    Romero, F.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197
  • [29] ULTRASTRUCTURAL FEATURES OF TYPE-II ALVEOLAR EPITHELIAL-CELLS IN EARLY EMBRYONIC MOUSE LUNG
    TENHAVEOPBROEK, AAW
    DUBBELDAM, JA
    OTTOVERBERNE, CJM
    ANATOMICAL RECORD, 1988, 221 (04): : 846 - 853
  • [30] Induction of type II alveolar epithelial cells apoptosis in mouse by lipopolysaccharide does not require TNF-α
    Song, Y
    Shi, Y
    Harken, AH
    Meng, XZ
    CHINESE MEDICAL JOURNAL, 2003, 116 (04) : 625 - 629
12345