Alveolar Epithelial Type II Cells and Their Microenvironment in the Caveolin-1-Deficient Mouse

被引：7

作者：

Jung, Kristina ^{[2
]}

Schlenz, Heike ^{[2
]}

Krasteva, Gabriela ^{[2
]}

Muehlfeld, Christian ^{[1
,2
]}

机构：

[1] Hannover Med Sch, Inst Funct & Appl Anat, D-30625 Hannover, Germany

[2] Univ Giessen, Inst Anat & Cell Biol, Giessen, Germany

来源：

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY | 2012年 / 295卷 / 02期

关键词：

caveolin-1; caveolae; Type II cells; electron microscopy; stereology; PULMONARY SURFACTANT SYSTEM; LUNG; EXPRESSION; CAVEOLAE; MICE;

D O I：

10.1002/ar.21543

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Caveolin-1 (Cav-1) is highly expressed in alveolar epithelial type I (AE1) and endothelial cells of the alveolar region of the lung. Interestingly, alveolar epithelial type II (AE2) cells that are progenitors of the AE1 cells do not express Cav-1. We investigated whether genetic Cav-1 deficiency alters the phenotype of AE2 cells and their microenvironment using stereology. Total number, mean volume, and subcellular composition of the AE2 cells were not altered in Cav-1-/- when compared with wild-type mice. The alveolar septa were thickened and contained a significantly greater volume of extracellular matrix. Thus, AE2 cells as progenitors of AE1 cells are not critically involved in the severe pulmonary phenotype in Cav-1-deficient mice. Anat Rec, 2012. (C) 2011 Wiley Periodicals, Inc.

引用

页码：196 / 200

页数：5

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