Anti-Hepatitis B Virus and Cytotoxic Diterpenoids from Isodon lophanthoides var. gerardianus

被引：33
|
作者：
Yang, Li-bin [1 ,2 ]
Li, Lin [3 ]
Huang, Sheng-xiong [1 ]
Pu, Jian-xin [1 ]
Zhao, Yong [1 ]
Ma, Yun-bao [1 ]
Chen, Ji-jun [1 ]
Leng, Chun-hong [3 ]
Tao, Zheng-ming [3 ]
Sun, Han-dong [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
[2] Xian Med Univ, Xian 710021, Shanxi, Peoples R China
[3] Zhejiang Inst Subtrop Crops, Wenzhou 325005, Zhejiang, Peoples R China
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2011年 / 59卷 / 09期
关键词：
Isodon lophanthoides var. gerardianus; diterpenoid; anti-hepatitis B virus; TUMOR-CELL LINES; RABDOSIA-LOPHANTHOIDES; ABIETANE QUINONES; DIVERSE PANEL; ASSAY;
D O I：
10.1248/cpb.59.1102
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new diterpenoides, isolophanthins A-D (1-4) together with seven known abietane diterpenoides (5-11), have been isolated from Isodon lophanthoides var. gerardianus. The new diterpenoides were elucidated by spectroscopic analysis. Some of them showed significant activities against HBsAg and HBeAg of hepatitis B virus in Hep G 2.2.15 cells, as well as the human tumor cell lines, HL-60, A-549, MOLT-4, and BEL-7402.
引用
收藏
页码：1102 / 1105
页数：4
相关论文
共 50 条
  • [21] Four new diterpenoids from Isodon eriocalyx var. laxiflora
    Wang W.-G.
    Du X.
    Li X.-N.
    Yan B.-C.
    Zhou M.
    Wu H.-Y.
    Zhan R.
    Dong K.
    Pu J.-X.
    Sun H.-D.
    Natural Products and Bioprospecting, 2013, 3 (4) : 145 - 149
  • [22] Cytotoxic 3,20-Epoxy-ent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflora
    Niu, XM
    Li, SH
    Mei, SX
    Na, Z
    Zhao, QS
    Lin, ZW
    Sun, HD
    JOURNAL OF NATURAL PRODUCTS, 2002, 65 (12): : 1892 - 1896
  • [23] ent-kaurane diterpenoids from Isodon angustifolius var. glabresecens
    Zhao, QS
    Tian, J
    Yue, JM
    Lin, ZW
    Sun, HD
    JOURNAL OF NATURAL PRODUCTS, 1997, 60 (11): : 1075 - 1081
  • [24] ENT-kaurane diterpenoids from Isodon rubescens var. Lushiensis
    Han, QB
    Li, SH
    Peng, LY
    Sun, HD
    HETEROCYCLES, 2003, 60 (04) : 933 - 938
  • [25] Anti-hepatitis B Virus Activity of 8-epi-Kingiside in Jasminum officinale var. grandiflorum
    ZHAO Gui-qin
    YIN Zhi-feng
    LIU Li-yan
    MAO Xiao-xia
    SU Zhan-hui
    Chinese Herbal Medicines, 2013, 5 (01) : 53 - 57
  • [26] Anti-hepatitis B Virus Activity of 8-epi-Kingiside in Jasminum officinale var. grandiflorum
    ZHAO Gui-qin
    YIN Zhi-feng
    LIU Li-yan
    MAO Xiao-xia
    SU Zhan-hui
    Chinese Herbal Medicines, 2013, (01) : 53 - 57
  • [27] Anti-hepatitis B Virus Activity of 8-epi-Kingiside in Jasminum officinale var. grandiflorum
    Zhao Gui-qin
    Yin Zhi-feng
    Liu Li-yan
    Mao Xiao-xia
    Su Zhan-hui
    CHINESE HERBAL MEDICINES, 2013, 5 (01) : 53 - 57
  • [28] ent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflora
    Wang Weiguang
    Wu Haiyan
    Du Xue
    Yan Juming
    Li Yan
    Pu Jianxin
    Sun Handong
    CHINESE JOURNAL OF CHEMISTRY, 2012, 30 (06) : 1226 - 1230
  • [29] Ent-kaurane diterpenoids from Isodon rubescens var. rubescens
    Han, QB
    Xiao, WL
    Shen, YH
    Sun, HD
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2004, 52 (06) : 767 - 769
  • [30] Two novel tricyclic diterpenoids from Isodon rubescens var. taihangensis
    Han, QB
    Zhang, JX
    Zhao, AH
    Sun, HD
    Lu, Y
    Wu, YS
    Zheng, QT
    TETRAHEDRON, 2004, 60 (10) : 2373 - 2377
12345