Anti-Hepatitis B Virus and Cytotoxic Diterpenoids from Isodon lophanthoides var. gerardianus

被引：33
|
作者：
Yang, Li-bin [1 ,2 ]
Li, Lin [3 ]
Huang, Sheng-xiong [1 ]
Pu, Jian-xin [1 ]
Zhao, Yong [1 ]
Ma, Yun-bao [1 ]
Chen, Ji-jun [1 ]
Leng, Chun-hong [3 ]
Tao, Zheng-ming [3 ]
Sun, Han-dong [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
[2] Xian Med Univ, Xian 710021, Shanxi, Peoples R China
[3] Zhejiang Inst Subtrop Crops, Wenzhou 325005, Zhejiang, Peoples R China
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2011年 / 59卷 / 09期
关键词：
Isodon lophanthoides var. gerardianus; diterpenoid; anti-hepatitis B virus; TUMOR-CELL LINES; RABDOSIA-LOPHANTHOIDES; ABIETANE QUINONES; DIVERSE PANEL; ASSAY;
D O I：
10.1248/cpb.59.1102
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new diterpenoides, isolophanthins A-D (1-4) together with seven known abietane diterpenoides (5-11), have been isolated from Isodon lophanthoides var. gerardianus. The new diterpenoides were elucidated by spectroscopic analysis. Some of them showed significant activities against HBsAg and HBeAg of hepatitis B virus in Hep G 2.2.15 cells, as well as the human tumor cell lines, HL-60, A-549, MOLT-4, and BEL-7402.
引用
收藏
页码：1102 / 1105
页数：4
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