Anti-Hepatitis B Virus and Cytotoxic Diterpenoids from Isodon lophanthoides var. gerardianus

被引：33

作者：

Yang, Li-bin ^{[1
,2
]}

Li, Lin ^{[3
]}

Huang, Sheng-xiong ^{[1
]}

Pu, Jian-xin ^{[1
]}

Zhao, Yong ^{[1
]}

Ma, Yun-bao ^{[1
]}

Chen, Ji-jun ^{[1
]}

Leng, Chun-hong ^{[3
]}

Tao, Zheng-ming ^{[3
]}

Sun, Han-dong ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[2] Xian Med Univ, Xian 710021, Shanxi, Peoples R China

[3] Zhejiang Inst Subtrop Crops, Wenzhou 325005, Zhejiang, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2011年 / 59卷 / 09期

关键词：

Isodon lophanthoides var. gerardianus; diterpenoid; anti-hepatitis B virus; TUMOR-CELL LINES; RABDOSIA-LOPHANTHOIDES; ABIETANE QUINONES; DIVERSE PANEL; ASSAY;

D O I：

10.1248/cpb.59.1102

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new diterpenoides, isolophanthins A-D (1-4) together with seven known abietane diterpenoides (5-11), have been isolated from Isodon lophanthoides var. gerardianus. The new diterpenoides were elucidated by spectroscopic analysis. Some of them showed significant activities against HBsAg and HBeAg of hepatitis B virus in Hep G 2.2.15 cells, as well as the human tumor cell lines, HL-60, A-549, MOLT-4, and BEL-7402.

引用

页码：1102 / 1105

页数：4

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