PREPARATION AND CHARACTERISATION OF INCLUSION COMPLEXES OF MELOXICAM AND α-CYCLODEXTRIN AND β-CYCLODEXTRIN

被引：0
|
作者：
Miclea, Lenuta-Maria [1 ]
Vlaia, Lavinia [1 ]
Vlaia, V. [2 ]
Hadaruga, Daniel I. [3 ]
Mircioiu, Constantin [4 ]
机构：
[1] Univ Med & Farm Timisoara, Dept Pharmaceut Technol, Fac Pharm, Timisoara 300041, Romania
[2] Univ Med & Farm Timisoara, Dept Organ Chem, Fac Pharm, Timisoara 300041, Romania
[3] Politehn Univ Timisoara, Fac Ind Chem & Environm Engn, Timisoara 300006, Romania
[4] Univ Med & Pharm Carol Davila, Fac Pharm, Dept Appl Math & Biostat, Bucharest 020956, Romania
来源：
FARMACIA | 2010年 / 58卷 / 05期
关键词：
Meloxicam; inclusion complexes; alpha-cyclodextrin; beta-; cyclodextrin; DISSOLUTION; SOLUBILITY; BINARY;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Meloxicam (ME) belongs to the thiazines antiinflammatory (AI) class, has antiinflammatory action, and is characterized by a low solubility in water. In order to increase its solubility in water, inclusion complexes of meloxicam with alpha-cyclodextrin (alpha-CD) and beta-cyclodextrin (beta-CD) were obtained. In order to obtain the complexes as particles of small (nanometric) dimensions, complexation by the co-precipitation, kneading and ethanol-water solution methods was used. The obtained inclusion complexes were characterized through Scanning Electron Microscopy (SEM) for the evaluation of the crystals' morphology and their approximate size and through thermal analysis using the thermogravimetric (TG) method and differential scanning calorimetry (DSC). The results obtained confirm the inclusion of meloxicam in the cyclodextrin cavity.
引用
收藏
页码：583 / 593
页数：11
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