PREPARATION AND CHARACTERISATION OF INCLUSION COMPLEXES OF MELOXICAM AND α-CYCLODEXTRIN AND β-CYCLODEXTRIN

被引：0

作者：

Miclea, Lenuta-Maria ^{[1
]}

Vlaia, Lavinia ^{[1
]}

Vlaia, V. ^{[2
]}

Hadaruga, Daniel I. ^{[3
]}

Mircioiu, Constantin ^{[4
]}

机构：

[1] Univ Med & Farm Timisoara, Dept Pharmaceut Technol, Fac Pharm, Timisoara 300041, Romania

[2] Univ Med & Farm Timisoara, Dept Organ Chem, Fac Pharm, Timisoara 300041, Romania

[3] Politehn Univ Timisoara, Fac Ind Chem & Environm Engn, Timisoara 300006, Romania

[4] Univ Med & Pharm Carol Davila, Fac Pharm, Dept Appl Math & Biostat, Bucharest 020956, Romania

来源：

FARMACIA | 2010年 / 58卷 / 05期

关键词：

Meloxicam; inclusion complexes; alpha-cyclodextrin; beta-; cyclodextrin; DISSOLUTION; SOLUBILITY; BINARY;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Meloxicam (ME) belongs to the thiazines antiinflammatory (AI) class, has antiinflammatory action, and is characterized by a low solubility in water. In order to increase its solubility in water, inclusion complexes of meloxicam with alpha-cyclodextrin (alpha-CD) and beta-cyclodextrin (beta-CD) were obtained. In order to obtain the complexes as particles of small (nanometric) dimensions, complexation by the co-precipitation, kneading and ethanol-water solution methods was used. The obtained inclusion complexes were characterized through Scanning Electron Microscopy (SEM) for the evaluation of the crystals' morphology and their approximate size and through thermal analysis using the thermogravimetric (TG) method and differential scanning calorimetry (DSC). The results obtained confirm the inclusion of meloxicam in the cyclodextrin cavity.

引用

页码：583 / 593

页数：11

共 50 条

[31] Preparation and Characterisation of Zinc Diethyldithiocarbamate-Cyclodextrin Inclusion Complexes for Potential Lung Cancer Treatment
Kaya, Ayse
Arafat, Basel
Chichger, Havovi
Tolaymat, Ibrahim
Pierscionek, Barbara
Khoder, Mouhamad
Najlah, Mohammad
PHARMACEUTICS, 2024, 16 (01)
[32] Supramolecular chemistry in cyclodextrin inclusion complexes: The formation rules of terpenes/β-cyclodextrin inclusion complexes
Kou, Xingran
Xu, Xiwei
Gao, Nan
Zhang, Yunchong
Huang, Xin
Chen, Feng
Ke, Qinfei
Meng, Qingran
FOOD HYDROCOLLOIDS, 2024, 157
[33] Study of inclusion complexes of valsartan with β-cyclodextrin and hydroxypropyl β-cyclodextrin
Nalawade, Pravin
Kadam, Vilasrao
Hirlekar, Rajashree
JOURNAL OF SCIENTIFIC & INDUSTRIAL RESEARCH, 2010, 69 (04): : 295 - 299
[34] Inclusion complexes of fluorofenidone with β-cyclodextrin and hydroxypropyl-β-cyclodextrin
Wang, Shengfeng
Ding, Yanfei
Yao, Yao
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2009, 35 (07) : 808 - 813
[35] Inclusion complexes of squalene with beta-cyclodextrin and methyl-beta-cyclodextrin: preparation and characterization
Nguyen, Anh Van
Deineka, Victor I.
Vu, Anh Thi Ngoc
Le, Tuan Dinh
Tran-Trung, Hieu
Nguyen, Tien A.
TURKISH JOURNAL OF CHEMISTRY, 2023, 47 (01) : 294 - +
[36] Inclusion complexes of ketosteroids with β-cyclodextrin
Forgo, P
Vincze, I
Kövér, KE
STEROIDS, 2003, 68 (04) : 321 - 327
[37] Physicochemical and release characterisation of garlic oil-β-cyclodextrin inclusion complexes
Wang, Jing
Cao, Yanping
Sun, Baoguo
Wang, Chengtao
FOOD CHEMISTRY, 2011, 127 (04) : 1680 - 1685
[38] Inclusion Complexes of γ-Cyclodextrin with Pendimethalin
Yu Chi
Fan Tengfei
Guo Xinyu
Wu Xuemin
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2015, 36 (02): : 306 - 309
[39] Preparation and characterization of inclusion complexes of carvedilol with methyl-β-cyclodextrin
Hirlekar, Rajashree
Kadam, Vilasrao
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2009, 63 (3-4) : 219 - 224
[40] Preparation of inclusion complexes of cyclodextrin with π-conjugated polymers and their optical properties
Yamaguchi, I
Nurulla, I
Yamamoto, T
KOBUNSHI RONBUNSHU, 2000, 57 (07) : 472 - 473

← 1 2 3 4 5 →