PREPARATION AND CHARACTERISATION OF INCLUSION COMPLEXES OF MELOXICAM AND α-CYCLODEXTRIN AND β-CYCLODEXTRIN

Meloxicam (ME) belongs to the thiazines antiinflammatory (AI) class, has antiinflammatory action, and is characterized by a low solubility in water. In order to increase its solubility in water, inclusion complexes of meloxicam with alpha-cyclodextrin (alpha-CD) and beta-cyclodextrin (beta-CD) were obtained. In order to obtain the complexes as particles of small (nanometric) dimensions, complexation by the co-precipitation, kneading and ethanol-water solution methods was used. The obtained inclusion complexes were characterized through Scanning Electron Microscopy (SEM) for the evaluation of the crystals' morphology and their approximate size and through thermal analysis using the thermogravimetric (TG) method and differential scanning calorimetry (DSC). The results obtained confirm the inclusion of meloxicam in the cyclodextrin cavity.