mRNA methylation by NSUN2 in cell proliferation

被引：31

作者：

Wang, Wengong ^{[1
]}

机构：

[1] Peking Univ, Beijing Key Lab Prot Posttranslat Modificat & Cel, Sch Basic Med Sci, Dept Biochem & Mol Biol,Hlth Sci Ctr, Beijing, Peoples R China

来源：

WILEY INTERDISCIPLINARY REVIEWS-RNA | 2016年 / 7卷 / 06期

基金：

美国国家科学基金会;

关键词：

DELAYS REPLICATIVE SENESCENCE; METHYLTRANSFERASE MISU NSUN2; 16S RIBOSOMAL-RNA; ESCHERICHIA-COLI; TRANSLATION; MYC; INITIATION; STABILITY; RESIDUES; GROWTH;

D O I：

10.1002/wrna.1380

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Methylation is a prevalent post-transcriptional modification that occurs in almost all RNA species. NSUN2, a nucleolar RNA methyltransferase, has been shown to methylate mRNAs encoding factors that control cell division and growth arrest, thereby affecting their stability and/or translation. Here, the author summarizes the recent progress in understanding NSUN2-mediated mRNA methylation and its implications in cell proliferation and senescence.

引用

页码：838 / 842

页数：5

共 50 条

[41] NSUN2 is critical for mouse oocyte meiosis and early embryonic development
Xu, Tengteng
Gao, Min
Zhang, Ling
Cao, Tianqi
Qiu, Yanling
Liu, Simiao
Wu, Wenlian
Zhou, Yitong
Liu, Haiying
Zhang, Rui
Ruan, Xiaohong
Huang, Junjiu
REPRODUCTION, 2024, 168 (06)
[42] The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability
Hussain, Shobbir
Benavente, Sandra Blanco
Nascimento, Elisabete
Dragoni, Ilaria
Kurowski, Agata
Gillich, Astrid
Humphreys, Peter
Frye, Michaela
JOURNAL OF CELL BIOLOGY, 2009, 186 (01): : 27 - 40
[43] RNA Cytosine Methyltransferases NSUN1 and NSUN2 Mediate the Lineage-Associated Resistance to Venetoclax in Leukemia
Wood, Shaun
Willbanks, Amber
Cheng, Jason Xiaojun
BLOOD, 2020, 136
[44] Transfer RNA methyltransferase gene NSUN2 mRNA expression modifies the effect of T cell activation score on patient survival in head and neck squamous carcinoma
Lu, Lingeng
Gaffney, Stephen G.
Cannataro, Vincent L.
Townsend, Jeffrey
ORAL ONCOLOGY, 2020, 101
[45] NSUN2 Promotes Tumor Progression and Regulates Immune Infiltration in Nasopharyngeal Carcinoma
Tong, Xinya
Xiang, Yilan
Hu, Yuanbo
Hu, Yingying
Li, He
Wang, Huilin
Zhao, Kong-Nan
Xue, Xiangyang
Zhu, Shanli
FRONTIERS IN ONCOLOGY, 2022, 12
[46] Pancancer Analysis of NSUN2 with a Focus on Prognostic and Immunological Roles in Endometrial Cancer
Zan, Yuxin
Ding, Yan
REPRODUCTIVE SCIENCES, 2024, : 1459 - 1476
[47] Division of labour: tRNA methylation by the NSun2 tRNA methyltransferases Trm4a and Trm4b in fission yeast
Mueller, Martin
Samel-Pommerencke, Anke
Legrand, Carine
Tuorto, Francesca
Lyko, Frank
Ehrenhofer-Murray, Ann E.
RNA BIOLOGY, 2019, 16 (03) : 249 - 256
[48] RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence
Cai, Xiaoyu
Hu, Yuanyuan
Tang, Hao
Hu, Han
Pang, Lijun
Xing, Junyue
Liu, Zhenyun
Luo, Yuhong
Jiang, Bin
Liu, Te
Gorospe, Myriam
Chen, Chuan
Wang, Wengong
ONCOTARGET, 2016, 7 (15) : 19099 - 19110
[49] NSun2在胃癌中的作用及机制初探
李春雅
黄凌云
李思琦
种悦阳
商瑜
北京师范大学学报(自然科学版), 2023, 59 (04) : 598 - 606
[50] RNA methyltransferase NSun2 deficiency ameliorates abdominal aortic aneurysm development by inhibiting T cell migration
Miao, Y.
Wang, X.
Feng, J.
EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 652 - 652

← 1 2 3 4 5 →