mRNA methylation by NSUN2 in cell proliferation

被引：31
|
作者：
Wang, Wengong [1 ]
机构：
[1] Peking Univ, Beijing Key Lab Prot Posttranslat Modificat & Cel, Sch Basic Med Sci, Dept Biochem & Mol Biol,Hlth Sci Ctr, Beijing, Peoples R China
来源：
WILEY INTERDISCIPLINARY REVIEWS-RNA | 2016年 / 7卷 / 06期
基金：
美国国家科学基金会;
关键词：
DELAYS REPLICATIVE SENESCENCE; METHYLTRANSFERASE MISU NSUN2; 16S RIBOSOMAL-RNA; ESCHERICHIA-COLI; TRANSLATION; MYC; INITIATION; STABILITY; RESIDUES; GROWTH;
D O I：
10.1002/wrna.1380
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Methylation is a prevalent post-transcriptional modification that occurs in almost all RNA species. NSUN2, a nucleolar RNA methyltransferase, has been shown to methylate mRNAs encoding factors that control cell division and growth arrest, thereby affecting their stability and/or translation. Here, the author summarizes the recent progress in understanding NSUN2-mediated mRNA methylation and its implications in cell proliferation and senescence.
引用
收藏
页码：838 / 842
页数：5
相关论文
共 50 条
  • [31] Mammalian NSUN2 introduces 5-methylcytidines into mitochondrial tRNAs
    Shinoda, Saori
    Kitagawa, Sho
    Nakagawa, Shinichi
    Wei, Fan-Yan
    Tomizawa, Kazuhito
    Araki, Kimi
    Araki, Masatake
    Suzuki, Takeo
    Suzuki, Tsutomu
    NUCLEIC ACIDS RESEARCH, 2019, 47 (16) : 8734 - 8745
  • [32] NSUN2 mediates distinct pathways to regulate enterovirus 71 replication
    Liu, Lishi
    Chen, Zhen
    Zhang, Kui
    Hao, Haojie
    Ma, Li
    Liu, Haizhou
    Yu, Baocheng
    Ding, Shuang
    Zhang, Xueyan
    Zhu, Miao
    Guo, Xiang
    Liu, Yi
    Liu, Haibin
    Huang, Fang
    Peng, Ke
    Guan, Wuxiang
    VIROLOGICA SINICA, 2024, 39 (04) : 574 - 586
  • [33] 顺铂处理的肺癌细胞NSUN2 mRNA剪接异构体变化
    吴小海
    刘晓晓
    张宏伟
    李梦仙
    温艳萍
    李明阳
    吴翰欣
    张沛
    俞建昆
    贵州医科大学学报, 2020, 45 (10) : 1164 - 1171
  • [34] 5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader
    Xin Yang
    Ying Yang
    Bao-Fa Sun
    Yu-Sheng Chen
    Jia-Wei Xu
    Wei-Yi Lai
    Ang Li
    Xing Wang
    Devi Prasad Bhattarai
    Wen Xiao
    Hui-Ying Sun
    Qin Zhu
    Hai-Li Ma
    Samir Adhikari
    Min Sun
    Ya-Juan Hao
    Bing Zhang
    Chun-Min Huang
    Niu Huang
    Gui-Bin Jiang
    Yong-Liang Zhao
    Hai-Lin Wang
    Ying-Pu Sun
    Yun-Gui Yang
    Cell Research, 2017, 27 : 606 - 625
  • [35] Effects of NSUN2 deficiency on the mRNA 5-methylcytosine modification and gene expression profile in HEK293 cells
    Sun, Zhen
    Xue, Songlei
    Xu, Hui
    Hu, Xuming
    Chen, Shihao
    Yang, Zhe
    Yang, Yu
    Ouyang, Juan
    Cui, Hengmi
    EPIGENOMICS, 2019, 11 (04) : 439 - 453
  • [36] RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57Kip2 by an m5C-dependent manner
    Mei, Lin
    Shen, Cheng
    Miao, Ran
    Wang, Jing-Zi
    Cao, Mend-Da
    Zhang, Yi-Sheng
    Shi, Liang-Hui
    Zhao, Guo-Hai
    Wang, Ming-Hai
    Wu, Li-Sheng
    Wei, Ji-Fu
    CELL DEATH & DISEASE, 2020, 11 (04)
  • [37] RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57Kip2 by an m5C-dependent manner
    Lin Mei
    Cheng Shen
    Ran Miao
    Jing-Zi Wang
    Mend-Da Cao
    Yi-Sheng Zhang
    Liang-Hui Shi
    Guo-Hai Zhao
    Ming-Hai Wang
    Li-Sheng Wu
    Ji-Fu Wei
    Cell Death & Disease, 11
  • [38] NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs
    Van Haute, Lindsey
    Lee, Song-Yi
    McCann, Beverly J.
    Powell, Christopher A.
    Bansal, Dhiru
    Vasiliauskaite, Lina
    Garone, Caterina
    Shin, Sanghee
    Kim, Jong-Seo
    Frye, Michaela
    Gleeson, Joseph G.
    Miska, Eric A.
    Rhee, Hyun-Woo
    Minczuk, Michal
    NUCLEIC ACIDS RESEARCH, 2019, 47 (16) : 8720 - 8733
  • [39] Glucose binds and activates NSUN2 to promote translation and epidermal differentiation
    Miao, Weili
    Porter, Douglas F.
    Li, Ya
    Meservey, Lindsey M.
    Yang, Yen-Yu
    Ma, Chengjie
    Ferguson, Ian D.
    Tien, Vivian B.
    Jack, Timothy M.
    Ducoli, Luca
    Lopez-Pajares, Vanessa
    Tao, Shiying
    Savage, Paul B.
    Wang, Yinsheng
    Khavari, Paul A.
    NUCLEIC ACIDS RESEARCH, 2024, 52 (22) : 13577 - 13593
  • [40] A novel variant in NSUN2 causes intellectual disability in a Chinese family
    Yang, Qi
    Zhang, Qiang
    Qin, Zailong
    Yi, Shang
    Luo, Jingsi
    BMC MEDICAL GENOMICS, 2024, 17 (01)
12345