mRNA methylation by NSUN2 in cell proliferation

被引：31
|
作者：
Wang, Wengong [1 ]
机构：
[1] Peking Univ, Beijing Key Lab Prot Posttranslat Modificat & Cel, Sch Basic Med Sci, Dept Biochem & Mol Biol,Hlth Sci Ctr, Beijing, Peoples R China
来源：
WILEY INTERDISCIPLINARY REVIEWS-RNA | 2016年 / 7卷 / 06期
基金：
美国国家科学基金会;
关键词：
DELAYS REPLICATIVE SENESCENCE; METHYLTRANSFERASE MISU NSUN2; 16S RIBOSOMAL-RNA; ESCHERICHIA-COLI; TRANSLATION; MYC; INITIATION; STABILITY; RESIDUES; GROWTH;
D O I：
10.1002/wrna.1380
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Methylation is a prevalent post-transcriptional modification that occurs in almost all RNA species. NSUN2, a nucleolar RNA methyltransferase, has been shown to methylate mRNAs encoding factors that control cell division and growth arrest, thereby affecting their stability and/or translation. Here, the author summarizes the recent progress in understanding NSUN2-mediated mRNA methylation and its implications in cell proliferation and senescence.
引用
收藏
页码：838 / 842
页数：5
相关论文
共 50 条
  • [21] The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer
    Chellamuthu, Anitha
    Gray, Steven G.
    CELLS, 2020, 9 (08)
  • [22] NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation (vol 12, 842, 2021)
    Hu, Yuanbo
    Chen, Chenbin
    Tong, Xinya
    Chen, Sian
    Hu, Xianjing
    Pan, Bujian
    Sun, Xiangwei
    Chen, Zhiyuan
    Shi, Xinyu
    Hu, Yingying
    Shen, Xian
    Xue, Xiangyang
    Lu, Mingdong
    CELL DEATH & DISEASE, 2024, 15 (07):
  • [23] FOXC2-AS1 stabilizes FOXC2 mRNA via association with NSUN2 in gastric cancer cells
    Yan, Jijun
    Liu, Juntao
    Huang, Zhengbin
    Huang, Wenwei
    Lv, Jianfa
    HUMAN CELL, 2021, 34 (06) : 1755 - 1764
  • [24] STUB1-mediated ubiquitination and degradation of NSUN2 promotes hepatocyte ferroptosis by decreasing m5C methylation of Gpx4 mRNA
    Zhang, Xiaotian
    Zhang, Yihua
    Li, Rongrong
    Li, Yibo
    Wang, Qi
    Wang, Ying
    Chen, Xinying
    Wang, Weihua
    Pang, Erli
    Li, Yanyan
    Wang, Jia
    Zheng, Jinping
    Zhang, Junjie
    CELL REPORTS, 2024, 43 (11):
  • [25] FOXC2-AS1 stabilizes FOXC2 mRNA via association with NSUN2 in gastric cancer cells
    Jijun Yan
    Juntao Liu
    Zhengbin Huang
    Wenwei Huang
    Jianfa Lv
    Human Cell, 2021, 34 : 1755 - 1764
  • [26] Aurora-B regulates RNA methyltransferase NSUN2
    Sakita-Suto, Shiho
    Kanda, Akifumi
    Suzuki, Fumio
    Sato, Sunao
    Takata, Takashi
    Tatsuka, Masaaki
    MOLECULAR BIOLOGY OF THE CELL, 2007, 18 (03) : 1107 - 1117
  • [27] NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m5C methylation
    Zhang, Xuran
    An, Ke
    Ge, Xin
    Sun, Yuanyuan
    Wei, Jingyao
    Ren, Weihong
    Wang, Han
    Wang, Yueqin
    Du, Yue
    He, Lulu
    Li, Ouwen
    Zhou, Shaoxuan
    Shi, Yong
    Ren, Tong
    Yang, Yun-gui
    Kan, Quancheng
    Tian, Xin
    BREAST CANCER RESEARCH, 2024, 26 (01)
  • [28] Reorganization of the Landscape of Translated mRNAs in NSUN2-Deficient Cells and Specific Features of NSUN2 Target mRNAs
    Kossinova, Olga A.
    Gopanenko, Alexander, V
    Babaylova, Elena S.
    Tupikin, Alexey E.
    Kabilov, Marsel R.
    Malygin, Alexey A.
    Karpova, Galina G.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (17)
  • [29] Mutations in NSUN2 Cause Autosomal-Recessive Intellectual Disability
    Abbasi-Moheb, Lia
    Mertel, Sara
    Gonsior, Melanie
    Nouri-Vahid, Leyla
    Kahrizi, Kimia
    Cirak, Sebahattin
    Wieczorek, Dagmar
    Motazacker, M. Mahdi
    Esmaeeli-Nieh, Sahar
    Cremer, Kirsten
    Weissmann, Robert
    Tzschach, Andreas
    Garshasbi, Masoud
    Abedini, Seyedeh S.
    Najmabadi, Hossein
    Ropers, H. Hilger
    Sigrist, Stephan J.
    Kuss, Andreas W.
    AMERICAN JOURNAL OF HUMAN GENETICS, 2012, 90 (05) : 847 - 855
  • [30] NSun2 Promotes Cell Growth via Elevating Cyclin-Dependent Kinase 1 Translation
    Xing, Junyue
    Yi, Jie
    Cai, Xiaoyu
    Tang, Hao
    Liu, Zhenyun
    Zhang, Xiaotian
    Martindale, Jennifer L.
    Yang, Xiaoling
    Jiang, Bin
    Gorospe, Myriam
    Wang, Wengong
    MOLECULAR AND CELLULAR BIOLOGY, 2015, 35 (23) : 4043 - 4052
12345