β-lactam derivatives as potential anti-cancer compounds

被引：17

作者：

Ruf, Sabine ^{[1
]}

Neudert, Gerd ^{[1
]}

Guertler, Susanne ^{[1
]}

Gruenert, Renate ^{[1
]}

Bednarski, Patrick J. ^{[1
]}

Otto, Hans-Hartwig ^{[1
]}

机构：

[1] Ernst Moritz Arndt Univ Greifswald, Dept Pharmaceut Med Chem, Inst Pharm, D-17487 Greifswald, Germany

来源：

MONATSHEFTE FUR CHEMIE | 2008年 / 139卷 / 07期

关键词：

beta-lactams; anti-cancer compounds;

D O I：

10.1007/s00706-007-0838-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A number of 1,4-diaryl-3-methylene substituted beta-lactams, the addition products obtained from their reactions with N-, S-, and C-nucleophiles, and diverse related compounds were prepared, and a selection of 43 compounds was screened in preliminary tests as anti-tumor compounds by using 4 or 5 human cancer cell lines of diverse origins. Twelve compounds were highly active against all cell lines, 6 showed low activity, 12 no activity, and 13 exhibited a selective activity against a human small cell lung carcinoma cell line.

引用

页码：847 / 857

页数：11

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