β-lactam derivatives as potential anti-cancer compounds

被引：17

作者：

Ruf, Sabine ^{[1
]}

Neudert, Gerd ^{[1
]}

Guertler, Susanne ^{[1
]}

Gruenert, Renate ^{[1
]}

Bednarski, Patrick J. ^{[1
]}

Otto, Hans-Hartwig ^{[1
]}

机构：

[1] Ernst Moritz Arndt Univ Greifswald, Dept Pharmaceut Med Chem, Inst Pharm, D-17487 Greifswald, Germany

来源：

MONATSHEFTE FUR CHEMIE | 2008年 / 139卷 / 07期

关键词：

beta-lactams; anti-cancer compounds;

D O I：

10.1007/s00706-007-0838-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A number of 1,4-diaryl-3-methylene substituted beta-lactams, the addition products obtained from their reactions with N-, S-, and C-nucleophiles, and diverse related compounds were prepared, and a selection of 43 compounds was screened in preliminary tests as anti-tumor compounds by using 4 or 5 human cancer cell lines of diverse origins. Twelve compounds were highly active against all cell lines, 6 showed low activity, 12 no activity, and 13 exhibited a selective activity against a human small cell lung carcinoma cell line.

引用

页码：847 / 857

页数：11

共 50 条

[21] Synthesis and biological evaluation of Schizandrin derivatives as potential anti-cancer agents
Amujuri, Devi
Siva, Bandi
Poornima, B.
Sirisha, Katukuri
Sarma, A. V. S.
Nayak, V. Lakshma
Tiwari, Ashok K.
Purushotham, U.
Babu, K. Suresh
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 149 : 182 - 192
[22] SYNTHESIS OF AMINOANTHRAQUINONE DERIVATIVES AND THEIR INVITRO EVALUATION AS POTENTIAL ANTI-CANCER DRUGS
KATZHENDLER, J
GEAN, KF
BARAD, G
TASHMA, Z
BENSHOSHAN, R
RINGEL, I
BACHRACH, U
RAMU, A
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1989, 24 (01) : 23 - 30
[23] Anti-Cancer Potential of Synthetic Oleanolic Acid Derivatives and Their Conjugates with NSAIDs
Baer-Dubowska, Wanda
Narozna, Maria
Krajka-Kuzniak, Violetta
MOLECULES, 2021, 26 (16):
[24] Synthesis of new polyamine-0-lactam conjugates as potential anti-cancer agents.
Zanardi, F
Varchi, G
Battaglia, A
Ojima, I
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U925 - U925
[25] A Survey of Marine Natural Compounds and Their Derivatives with Anti-Cancer Activity Reported in 2010
Schumacher, Marc
Kelkel, Mareike
Dicato, Mario
Diederich, Marc
MOLECULES, 2011, 16 (07): : 5629 - 5646
[26] Towards lead compounds as anti-cancer agents via new phaeosphaeride A derivatives
Abzianidze, Victoria V.
Zakharenkova, Sofya A.
Moiseeva, Natalia, I
Beltyukov, Petr P.
Polukeev, Valeriy A.
Dubrovskii, Yaroslav A.
Kuznetsov, Victor A.
Trishin, Yuri G.
Mejia, Jennifer E.
Holder, Alvin A.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 29 (01) : 59 - 61
[27] Gold Derivatives as Anti-Cancer Agents
Rodriguez Raurell, Laura
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2011, 11 (10) : 920 - 920
[28] A Survey of Marine Natural Compounds and Their Derivatives with Anti-Cancer Activity Reported in 2012
Sawadogo, Wamtinga Richard
Boly, Rainatou
Cerella, Claudia
Teiten, Marie Helene
Dicato, Mario
Diederich, Marc
MOLECULES, 2015, 20 (04) : 7097 - 7142
[29] A Survey of Marine Natural Compounds and Their Derivatives with Anti-Cancer Activity Reported in 2011
Sawadogo, Wamtinga Richard
Schumacher, Marc
Teiten, Marie-Helene
Cerella, Claudia
Dicato, Mario
Diederich, Marc
MOLECULES, 2013, 18 (04) : 3641 - 3673
[30] ARNEBIN DERIVATIVES FOR ANTI-CANCER ACTIVITY
KATTI, SB
SHUKLA, YN
TANDON, JS
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1979, 18 (05): : 440 - 442

← 1 2 3 4 5 →