β-lactam derivatives as potential anti-cancer compounds

被引：17

作者：

Ruf, Sabine ^{[1
]}

Neudert, Gerd ^{[1
]}

Guertler, Susanne ^{[1
]}

Gruenert, Renate ^{[1
]}

Bednarski, Patrick J. ^{[1
]}

Otto, Hans-Hartwig ^{[1
]}

机构：

[1] Ernst Moritz Arndt Univ Greifswald, Dept Pharmaceut Med Chem, Inst Pharm, D-17487 Greifswald, Germany

来源：

MONATSHEFTE FUR CHEMIE | 2008年 / 139卷 / 07期

关键词：

beta-lactams; anti-cancer compounds;

D O I：

10.1007/s00706-007-0838-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A number of 1,4-diaryl-3-methylene substituted beta-lactams, the addition products obtained from their reactions with N-, S-, and C-nucleophiles, and diverse related compounds were prepared, and a selection of 43 compounds was screened in preliminary tests as anti-tumor compounds by using 4 or 5 human cancer cell lines of diverse origins. Twelve compounds were highly active against all cell lines, 6 showed low activity, 12 no activity, and 13 exhibited a selective activity against a human small cell lung carcinoma cell line.

引用

页码：847 / 857

页数：11

共 50 条

[31] Biotechnological Production of Anti-cancer Compounds
Malik, Sonia
CURRENT MEDICINAL CHEMISTRY, 2018, 25 (36) : 4654 - 4655
[32] Toxicity, Teratogenicity and Anti-cancer Activity of α-solanine: A Perspective on Anti-cancer Potential
Ordonez-Vasquez, Adriana
Aguirre-Arzola, Victor
Angelica De la Garza-Ramos, Myriam
Hugo Urrutia-Baca, Victor
Suarez-Obando, Fernando
INTERNATIONAL JOURNAL OF PHARMACOLOGY, 2019, 15 (03) : 301 - 310
[33] Anti-cancer potential of sophoridine and its derivatives: Recent progress and future perspectives
Rashid, Haroon Ur
Rasool, Shagufta
Ali, Yousaf
Khan, Kamin
Martines, Marco Antonio Utrera
BIOORGANIC CHEMISTRY, 2020, 99
[34] Sulfonylhydrazide Derivatives as Potential Anti-cancer Agents: Synthesis, In Vitro and In Silico Studies
Ibrahim, Kholoud M.
Elsisi, Doaa M.
Ammar, Yousry A.
Araki, Fivian F. M.
Micky, Jehane A. A.
PROTEIN JOURNAL, 2024, 43 (05): : 949 - 966
[35] ERGOT ALKALOIDS - SYNTHESIS OF NITROSOUREA DERIVATIVES OF ERGOLINES AS POTENTIAL ANTI-CANCER AGENTS
CRIDER, AM
LU, CKL
FLOSS, HG
CASSADY, JM
CLEMENS, JA
JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (01) : 32 - 35
[36] POTENTIAL ANTI-CANCER AGENTS .7. AZIDO-PURINE DERIVATIVES
ITAI, T
ITO, G
CHEMICAL & PHARMACEUTICAL BULLETIN, 1962, 10 (12) : 1141 - +
[37] Design and synthesis of new anthrapyrazole derivatives as potential anti-cancer agents.
Larson, KK
Lin, D
Begleiter, A
Guziec, FS
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 225 : U387 - U387
[38] POTENTIAL ANTI-CANCER AGENTS .27. NEW ALKYLATING DERIVATIVES OF ESTRADIOL
ELIAN, I
IONESCU, D
TARNAUCEANU, E
NICULESCUDUVAZ, I
LECLERCQ, G
DEVLEESCHOUWER, N
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1983, 18 (04) : 385 - 387
[39] Ursolic Acid-Based Derivatives as Potential Anti-Cancer Agents: An Update
Khwaza, Vuyolwethu
Oyedeji, Opeoluwa O.
Aderibigbe, Blessing A.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (16) : 1 - 27
[40] Synthesis and Cytotoxicity Evaluation of Novel Indole Derivatives as Potential Anti-Cancer Agents
Kamel, Mona M.
Abdel-hameid, Mohamed K.
El-Nassan, Hala B.
El-Khouly, Eman A.
MEDICINAL CHEMISTRY, 2019, 15 (08) : 873 - 882

← 1 2 3 4 5 →