Immune Responses to HIV Vaccines and Potential Impact on Control of Acute HIV-1 Infection

被引:13
|
作者
McElrath, M. Juliana [1 ]
机构
[1] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98109 USA
来源
基金
美国国家卫生研究院;
关键词
T-CELL RESPONSES; ESCAPE; COMBINATION; EVOLUTION; STEP;
D O I
10.1086/655658
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Unanticipated results from 2 recent candidate human immunodeficiency virus type 1 (HIV-1) vaccine regimens in large-scale international trials highlight the importance of understanding the optimal earliest immune defense against HIV-1 infection. Presented here are key findings in these vaccine studies with relevance to the development of future vaccines to control acute HIV-1 infection.
引用
收藏
页码:S323 / S326
页数:4
相关论文
共 50 条
  • [21] Control of HIV-1 infection by soluble factors of the immune response
    DeVico, AL
    Gallo, RC
    NATURE REVIEWS MICROBIOLOGY, 2004, 2 (05) : 401 - 413
  • [22] Viral vectors as potential HIV-1 vaccines
    Schnell, MJ
    FEMS MICROBIOLOGY LETTERS, 2001, 200 (02) : 123 - 129
  • [23] Control of HIV-1 infection by soluble factors of the immune response
    Anthony L. DeVico
    Robert C. Gallo
    Nature Reviews Microbiology, 2004, 2 : 401 - 413
  • [24] Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses correlate with control of acute HIV-1 infection in macaques
    Kent, SJ
    Woodward, A
    Zhao, A
    JOURNAL OF INFECTIOUS DISEASES, 1997, 176 (05): : 1188 - 1197
  • [25] Immune Checkpoints as the Immune System Regulators and Potential Biomarkers in HIV-1 Infection
    Sperk, Maike
    van Domselaar, Robert
    Neogi, Ujjwal
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (07)
  • [26] EARLY VIREMIA AND IMMUNE-RESPONSES IN VERTICAL HIV-1 INFECTION
    LUZURIAGA, K
    SULLIVAN, JL
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1993, : 94 - 94
  • [27] Humoral immune responses to Streptococcus pneumoniae in the setting of HIV-1 infection
    Zhang, Lumin
    Li, Zihai
    Wan, Zhuang
    Kilby, Andrew
    Kilby, J. Michael
    Jiang, Wei
    VACCINE, 2015, 33 (36) : 4430 - 4436
  • [28] Frequent and Strong NK Responses to HIV-1 Env Peptides in Individuals with Acute and Chronic HIV-1 Infection
    Thobakgale, C. F.
    Fadda, L.
    Lane, K.
    Pereyra, F.
    Walker, B. D.
    Allen, T.
    Altfeld, M.
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2011, 27 (10) : A5 - A5
  • [29] NK cells in HIV-1 infection: evidence for their role in the control of HIV-1 infection
    Alter, G.
    Altfeld, M.
    JOURNAL OF INTERNAL MEDICINE, 2009, 265 (01) : 29 - 42
  • [30] HIV-1 DNA vaccine with adjuvant cytokines induces specific immune responses against HIV-1 infection in mice
    WANG Fuxiang SUN Yongtao WANG Linxu and LIU JuanDepartment of Infectious Diseases Tangdu Hospital Fourth Military Medical University Xian China Department of Infectious Diseases First Clinical College Harbin Medical University Harbin China
    Chinese Medical Journal, 2006, (12) : 1034 - 1037