Immune Responses to HIV Vaccines and Potential Impact on Control of Acute HIV-1 Infection

被引:13
|
作者
McElrath, M. Juliana [1 ]
机构
[1] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98109 USA
来源
基金
美国国家卫生研究院;
关键词
T-CELL RESPONSES; ESCAPE; COMBINATION; EVOLUTION; STEP;
D O I
10.1086/655658
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Unanticipated results from 2 recent candidate human immunodeficiency virus type 1 (HIV-1) vaccine regimens in large-scale international trials highlight the importance of understanding the optimal earliest immune defense against HIV-1 infection. Presented here are key findings in these vaccine studies with relevance to the development of future vaccines to control acute HIV-1 infection.
引用
收藏
页码:S323 / S326
页数:4
相关论文
共 50 条
  • [32] HIV-1 DNA vaccine with adjuvant cytokines induces specific immune responses against HIV-1 infection in mice
    Wang Fu-xiang
    Sun Yong-tao
    Wang Lin-xu
    Liu Juan
    CHINESE MEDICAL JOURNAL, 2006, 119 (12) : 1034 - 1037
  • [33] Role of therapeutic vaccines in the control of HIV-1
    Kinloch-de Loes, S
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2004, 53 (04) : 562 - 566
  • [34] HIV-1 immune evasion—a threat to effective vaccines?
    Morgane Rolland
    Nature Medicine, 2016, 22 : 580 - 581
  • [35] Immune control of HIV-1 reservoirs
    Autran, Brigitte
    Descours, Benjamin
    Bacchus, Charline
    CURRENT OPINION IN HIV AND AIDS, 2013, 8 (03) : 204 - 210
  • [36] Immune control of HIV-1 replication
    Walker, BD
    Rosenberg, ES
    Hay, CM
    Basgoz, N
    Yang, OO
    MECHANISMS OF LYMPHOCYTE ACTIVATION AND IMMUNE REGULATION VII: MOLECULAR DETERMINANTS OF MICROBIAL IMMUNITY, 1998, 452 : 159 - 167
  • [37] Potential role of immune modulation in the effective long-term control of HIV-1 infection
    Rizzardi, GP
    Lazzarin, A
    Pantaleo, G
    JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2002, 16 (01): : 83 - 90
  • [38] HIV-1 vaccine induced immune responses in newborns of HIV-1 infected mothers
    McFarland, Elizabeth J.
    Johnson, Daniel C.
    Muresan, Petronella
    Fenton, Terence
    Tomaras, Georgia D.
    McNamara, James
    Read, Jennifer S.
    Douglas, Steven D.
    Deville, Jaime
    Gurwith, Marc
    Gurunathan, Sanjay
    Lambert, John S.
    AIDS, 2006, 20 (11) : 1481 - 1489
  • [39] HIV-1 and immune control: can we change the course of HIV-1?
    Kovacs, A
    Connors, M
    LANCET, 2004, 363 (9412): : 833 - 834
  • [40] Recent Advances in Lentiviral Vaccines for HIV-1 infection
    Norton, Thomas D.
    Miller, Elizabeth A.
    FRONTIERS IN IMMUNOLOGY, 2016, 7