Driving With No Brakes: Molecular Pathophysiology of Kv7 Potassium Channels

被引：134
|
作者：
Soldovieri, Maria Virginia [1 ]
Miceli, Francesco [2 ,3 ]
Taglialatela, Maurizio [1 ,2 ]
机构：
[1] Univ Molise, Dept Hlth Sci, Campobasso, Italy
[2] Univ Naples Federico II, Dept Neurosci, Naples, Italy
[3] IRCCS Bambino Gesu Childrens Hosp, Div Neurol, Rome, Italy
来源：
PHYSIOLOGY | 2011年 / 26卷 / 05期
关键词：
OUTER HAIR-CELLS; KCNQ K+ CHANNELS; I-KS; SKELETAL-MUSCLE; FUNCTIONAL-CHARACTERIZATION; SURFACE EXPRESSION; SIGNALING COMPLEX; MAMMALIAN-CELLS; C-TERMINUS; MODULATION;
D O I：
10.1152/physiol.00009.2011
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Kv7 potassium channels regulate excitability in neuronal, sensory, and muscular cells. Here, we describe their molecular architecture, physiological roles, and involvement in genetically determined channelopathies highlighting their relevance as targets for pharmacological treatment of several human disorders.
引用
收藏
页码：365 / 376
页数：12
相关论文
共 50 条
  • [41] Ligand modulation of KCNQ-encoded (Kv7) potassium channels in the heart and nervous system
    Naffaa, Moawiah M.
    Al-Ewaidat, Ola A.
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 906
  • [42] Analgesic Action of Acetaminophen via Kv7 Channels
    Stampf, Jan-Luca
    Ciotu, Cosmin I.
    Heber, Stefan
    Boehm, Stefan
    Fischer, Michael J. M.
    Salzer, Isabella
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (01)
  • [43] Does cure for pain REST on Kv7 channels?
    Passmore, Gayle
    Delmas, Patrick
    PAIN, 2011, 152 (04) : 709 - 710
  • [44] Polyunsaturated Fatty Acids as Modulators of KV7 Channels
    Larsson, Johan E.
    Frampton, Damon J. A.
    Liin, Sara I.
    FRONTIERS IN PHYSIOLOGY, 2020, 11
  • [45] Neuronal Kv7 channels: A new target for anxiolytics
    Hartz, BP
    Mirza, NR
    BEHAVIOURAL PHARMACOLOGY, 2005, 16 : S23 - S23
  • [46] Challenging dogmas: a decade of vascular Kv7 channels
    Greenwood, Iain
    Stott, Jennifer
    Carr, Georgina
    Jepps, Thomas
    JOURNAL OF VASCULAR RESEARCH, 2014, 51 : 156 - 156
  • [47] Gating currents from neuronal Kv7 channels
    Miceli, Francesco
    Campos, Fabiana V.
    Walter, Sandtner
    Soldovieri, Maria Virginia
    Annunziato, Lucio
    Taglialatela, Maurizio
    Bezanilla, Francisco
    BIOPHYSICAL JOURNAL, 2009, 96 (03) : 656A - 656A
  • [48] Editorial: Kv7 Channels: Structure, Physiology, and Pharmacology
    Jepps, Thomas A.
    Barrese, Vincenzo
    Miceli, Francesco
    FRONTIERS IN PHYSIOLOGY, 2021, 12
  • [49] Voltage Sensor Movement of Neuronal Kv7 Channels
    Edmond, Michaela
    Barro-Soria, Rene
    BIOPHYSICAL JOURNAL, 2020, 118 (03) : 113A - 113A
  • [50] The Role of Kv7 Channels in Neural Plasticity and Behavior
    Baculis, Brian C.
    Zhang, Jiaren
    Chung, Hee Jung
    FRONTIERS IN PHYSIOLOGY, 2020, 11
12345