Driving With No Brakes: Molecular Pathophysiology of Kv7 Potassium Channels

被引：134
|
作者：
Soldovieri, Maria Virginia [1 ]
Miceli, Francesco [2 ,3 ]
Taglialatela, Maurizio [1 ,2 ]
机构：
[1] Univ Molise, Dept Hlth Sci, Campobasso, Italy
[2] Univ Naples Federico II, Dept Neurosci, Naples, Italy
[3] IRCCS Bambino Gesu Childrens Hosp, Div Neurol, Rome, Italy
来源：
PHYSIOLOGY | 2011年 / 26卷 / 05期
关键词：
OUTER HAIR-CELLS; KCNQ K+ CHANNELS; I-KS; SKELETAL-MUSCLE; FUNCTIONAL-CHARACTERIZATION; SURFACE EXPRESSION; SIGNALING COMPLEX; MAMMALIAN-CELLS; C-TERMINUS; MODULATION;
D O I：
10.1152/physiol.00009.2011
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Kv7 potassium channels regulate excitability in neuronal, sensory, and muscular cells. Here, we describe their molecular architecture, physiological roles, and involvement in genetically determined channelopathies highlighting their relevance as targets for pharmacological treatment of several human disorders.
引用
收藏
页码：365 / 376
页数：12
相关论文
共 50 条
  • [31] Novel treatment strategies for smooth muscle disorders: Targeting Kv7 potassium channels
    Haick, Jennifer M.
    Byron, Kenneth L.
    PHARMACOLOGY & THERAPEUTICS, 2016, 165 : 14 - 25
  • [32] Kv7 Channels as Targets for the Treatment of Pain
    Wickenden, A. D.
    McNaughton-Smith, G.
    CURRENT PHARMACEUTICAL DESIGN, 2009, 15 (15) : 1773 - 1798
  • [33] Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds
    Xiong, Qiaojie
    Gao, Zhaobing
    Wang, Wei
    Li, Min
    TRENDS IN PHARMACOLOGICAL SCIENCES, 2008, 29 (02) : 99 - 107
  • [34] Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter
    Zhong, Xi Zoe
    Harhun, Maksym I.
    Olesen, Soren P.
    Ohya, Susumu
    Moffatt, James D.
    Cole, William C.
    Greenwood, Iain A.
    JOURNAL OF PHYSIOLOGY-LONDON, 2010, 588 (17): : 3277 - 3293
  • [35] New molecular targets for antiepileptic drugs: α2δ, SV2A, and Kv7/KCNQ/M potassium channels
    Michael A. Rogawski
    Carl W. Bazil
    Current Neurology and Neuroscience Reports, 2008, 8 : 345 - 352
  • [36] New molecular targets for Antiepileptic drugs:: α2δ, SV2A, and Kv7/KCNQ/M potassium channels
    Rogawski, Michael A.
    Bazil, Carl W.
    CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, 2008, 8 (04) : 345 - 352
  • [37] Functional and molecular characterization of Kv7 channels in murine gastrointestinal smooth muscles
    Ohya, Susumu
    Jepps, Thomas
    Greenwood, Iain
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, 106 : 256P - 256P
  • [38] Role of Kv7 Potassium Channels in The Morphine-Induced Antinociception in Acute and Neuropathic Pain
    Kahveci, Nevzat
    Gulec, Guldal
    Ozluk, Kasim
    JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, 2011, 28 (04): : 440 - 452
  • [39] Cardiovascular KCNQ (Kv7) Potassium Channels: Physiological Regulators and New Targets for Therapeutic Intervention
    Mackie, Alexander R.
    Byron, Kenneth L.
    MOLECULAR PHARMACOLOGY, 2008, 74 (05) : 1171 - 1179
  • [40] Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels
    van der Horst, Jennifer
    Greenwood, Iain A.
    Jepps, Thomas A.
    FRONTIERS IN PHYSIOLOGY, 2020, 11
12345