Driving With No Brakes: Molecular Pathophysiology of Kv7 Potassium Channels

被引：134
|
作者：
Soldovieri, Maria Virginia [1 ]
Miceli, Francesco [2 ,3 ]
Taglialatela, Maurizio [1 ,2 ]
机构：
[1] Univ Molise, Dept Hlth Sci, Campobasso, Italy
[2] Univ Naples Federico II, Dept Neurosci, Naples, Italy
[3] IRCCS Bambino Gesu Childrens Hosp, Div Neurol, Rome, Italy
来源：
PHYSIOLOGY | 2011年 / 26卷 / 05期
关键词：
OUTER HAIR-CELLS; KCNQ K+ CHANNELS; I-KS; SKELETAL-MUSCLE; FUNCTIONAL-CHARACTERIZATION; SURFACE EXPRESSION; SIGNALING COMPLEX; MAMMALIAN-CELLS; C-TERMINUS; MODULATION;
D O I：
10.1152/physiol.00009.2011
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Kv7 potassium channels regulate excitability in neuronal, sensory, and muscular cells. Here, we describe their molecular architecture, physiological roles, and involvement in genetically determined channelopathies highlighting their relevance as targets for pharmacological treatment of several human disorders.
引用
收藏
页码：365 / 376
页数：12
相关论文
共 50 条
  • [21] Kv7/M-type potassium channels in rat skin keratinocytes
    Joanne M. Reilly
    Vsevolod Telezhkin
    Gayle M. Passmore
    Stephen J. Marsh
    David A. Brown
    Pflügers Archiv - European Journal of Physiology, 2013, 465 : 1371 - 1381
  • [22] Kv7 potassium channels as signal transduction intermediates in the control of microvascular tone
    Byron, Kenneth L.
    Brueggemann, Lyubov I.
    MICROCIRCULATION, 2018, 25 (01)
  • [23] Kv7 potassium channels: a new therapeutic target in smooth muscle disorders
    Stott, Jennifer B.
    Jepps, Thomas A.
    Greenwood, Lain A.
    DRUG DISCOVERY TODAY, 2014, 19 (04) : 413 - 424
  • [24] Probing the Molecular Basis of Opposing PUFA Effects on KV7 Channels
    Frampton, Damon J. A.
    Abrahamsson, Louise C.
    Larsson, Johan E.
    Liin, Sara I.
    BIOPHYSICAL JOURNAL, 2020, 118 (03) : 109A - 109A
  • [25] Paracetamol metabolite modifications of Kv7 channels
    Stampf, Jan-Luca
    Yang, Jae-Won
    Ciotu, Cosmin I.
    Fischer, Michael J. M.
    Boehm, Stefan
    Salzer, Isabella
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2021, 50 (SUPPL 1): : 111 - 111
  • [26] Cannabidiol activates neuronal Kv7 channels
    Zhang, Han-Xiong Bear
    Heckman, Laurel
    Niday, Zachary
    Jo, Sooyeon
    Fujita, Akie
    Shim, Jaehoon
    Pandey, Roshan
    Al Jandal, Hoor
    Jayakar, Selwyn
    Barrett, Lee B.
    Smith, Jennifer
    Woolf, Clifford J.
    Bean, Bruce P.
    ELIFE, 2022, 11
  • [27] Modulation of Kv7 channels and excitability in the brain
    Derek L. Greene
    Naoto Hoshi
    Cellular and Molecular Life Sciences, 2017, 74 : 495 - 508
  • [28] Physiological and pharmacological regulation of Kv7 channels
    Olesen, S. P.
    Rasmussen, H. B.
    Jensen, H. S.
    Bentzen, B. H.
    FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2008, 22 : 27 - 27
  • [29] Modulation of Kv7 channels and excitability in the brain
    Greene, Derek L.
    Hoshi, Naoto
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2017, 74 (03) : 495 - 508
  • [30] Targeting Kv7 channels in pain pathways
    Rivera-Arconada, Ivan
    Vicente-Baz, Jorge
    Antonio Lopez-Garcia, Jose
    ONCOTARGET, 2017, 8 (08) : 12554 - 12555
12345