Driving With No Brakes: Molecular Pathophysiology of Kv7 Potassium Channels

被引：134
|
作者：
Soldovieri, Maria Virginia [1 ]
Miceli, Francesco [2 ,3 ]
Taglialatela, Maurizio [1 ,2 ]
机构：
[1] Univ Molise, Dept Hlth Sci, Campobasso, Italy
[2] Univ Naples Federico II, Dept Neurosci, Naples, Italy
[3] IRCCS Bambino Gesu Childrens Hosp, Div Neurol, Rome, Italy
来源：
PHYSIOLOGY | 2011年 / 26卷 / 05期
关键词：
OUTER HAIR-CELLS; KCNQ K+ CHANNELS; I-KS; SKELETAL-MUSCLE; FUNCTIONAL-CHARACTERIZATION; SURFACE EXPRESSION; SIGNALING COMPLEX; MAMMALIAN-CELLS; C-TERMINUS; MODULATION;
D O I：
10.1152/physiol.00009.2011
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Kv7 potassium channels regulate excitability in neuronal, sensory, and muscular cells. Here, we describe their molecular architecture, physiological roles, and involvement in genetically determined channelopathies highlighting their relevance as targets for pharmacological treatment of several human disorders.
引用
收藏
页码：365 / 376
页数：12
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