Depth-resolved analytical model and correction algorithm for photothermal optical coherence tomography

被引：16

作者：

Lapierre-Landry, Maryse ^{[1
]}

Tucker-Schwartz, Jason M. ^{[1
]}

Skala, Melissa C. ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Biomed Engn, Nashville, TN 37235 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2016年 / 7卷 / 07期

关键词：

IN-VIVO; INDOCYANINE GREEN; GOLD NANOPARTICLES; CONTRAST AGENTS; CANCER; ANGIOGENESIS; MICROSCOPY; ARTIFACTS; NANORODS; DELIVERY;

D O I：

10.1364/BOE.7.002607

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Photothermal OCT (PT-OCT) is an emerging molecular imaging technique that occupies a spatial imaging regime between microscopy and whole body imaging. PT-OCT would benefit from a theoretical model to optimize imaging parameters and test image processing algorithms. We propose the first analytical PT-OCT model to replicate an experimental A-scan in homogeneous and layered samples. We also propose the PT-CLEAN algorithm to reduce phase-accumulation and shadowing, two artifacts found in PT-OCT images, and demonstrate it on phantoms and in vivo mouse tumors. (C) 2016 Optical Society of America

引用

页码：2607 / 2622

页数：16

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