Depth-resolved analytical model and correction algorithm for photothermal optical coherence tomography

被引：16
|
作者：
Lapierre-Landry, Maryse [1 ]
Tucker-Schwartz, Jason M. [1 ]
Skala, Melissa C. [1 ]
机构：
[1] Vanderbilt Univ, Dept Biomed Engn, Nashville, TN 37235 USA
来源：
BIOMEDICAL OPTICS EXPRESS | 2016年 / 7卷 / 07期
关键词：
IN-VIVO; INDOCYANINE GREEN; GOLD NANOPARTICLES; CONTRAST AGENTS; CANCER; ANGIOGENESIS; MICROSCOPY; ARTIFACTS; NANORODS; DELIVERY;
D O I：
10.1364/BOE.7.002607
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Photothermal OCT (PT-OCT) is an emerging molecular imaging technique that occupies a spatial imaging regime between microscopy and whole body imaging. PT-OCT would benefit from a theoretical model to optimize imaging parameters and test image processing algorithms. We propose the first analytical PT-OCT model to replicate an experimental A-scan in homogeneous and layered samples. We also propose the PT-CLEAN algorithm to reduce phase-accumulation and shadowing, two artifacts found in PT-OCT images, and demonstrate it on phantoms and in vivo mouse tumors. (C) 2016 Optical Society of America
引用
收藏
页码：2607 / 2622
页数：16
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