Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography

被引：42
|
作者：
Aguirre, A. D. [1 ]
Chen, Y.
Fujimoto, J. G.
Ruvinskaya, L.
Devor, A.
Boas, D. A.
机构：
[1] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
[2] MIT, Elect Res Lab, Cambridge, MA 02139 USA
[3] Massachusetts Gen Hosp, Athinoula A Martinos Ctr, Charlestown, MA 02129 USA
来源：
OPTICS LETTERS | 2006年 / 31卷 / 23期
关键词：
NEURAL ACTIVITY; HEMOGLOBIN CONCENTRATION; SCATTERING CHANGES; BLOOD-FLOW; OXYGENATION;
D O I：
10.1364/OL.31.003459
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
Co-registered optical coherence tomography (OCT) and video microscopy of the rat somatosensory cortex were acquired simultaneously through a thinned skull during forepaw electrical stimulation. Fractional signal change measured by OCT revealed a functional signal time course corresponding to the hemodynamic signal measurement made with video microscopy. OCT can provide high-resolution, cross-sectional images of functional neurovascular activation and may offer a new tool for basic neuroscience research in the important rat cerebral cortex model. (c) 2006 Optical Society of America.
引用
收藏
页码：3459 / 3461
页数：3
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