Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?

被引：14

作者：

Rapacka-Zdonczyk, Aleksandra ^{[1
]}

Wozniak, Agata ^{[2
,3
]}

Kruszewska, Beata ^{[1
,2
,3
]}

Waleron, Krzysztof ^{[1
]}

Grinholc, Mariusz ^{[2
,3
]}

机构：

[1] Med Univ Gdansk, Fac Pharm, Dept Pharmaceut Microbiol, Hallera 107, PL-80416 Gdansk, Poland

[2] Univ Gdansk, Intercollegiate Fac Biotechnol, Lab Photobiol & Mol Diagnost, Abrahama 58, PL-80307 Gdansk, Poland

[3] Med Univ Gdansk, Abrahama 58, PL-80307 Gdansk, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 21期

关键词：

antimicrobial blue light; resistance; tolerance; Escherichia coli; Klebsiella pneumoniae; Pseudomonas aeruginosa; 405 NM LIGHT; PSEUDOMONAS-AERUGINOSA; STAPHYLOCOCCUS-AUREUS; IN-VITRO; SOLVENT TOLERANCE; ACID TOLERANCE; ERROR-PRONE; EFFLUX; INACTIVATION; PHOTOINACTIVATION;

D O I：

10.3390/ijms222111579

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antimicrobial blue light (aBL) treatment is considered low risk for the development of bacterial resistance and tolerance due to its multitarget mode of action. The aim of the current study was to demonstrate whether tolerance development occurs in Gram-negative bacteria. We evaluated the potential of tolerance/resistance development in Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa and demonstrated that representative Gram-negative bacteria may develop tolerance to aBL. The observed adaption was a stable feature. Assays involving E. coli K-12 tolC-, tolA-, umuD-, and recA-deficient mutants revealed some possible mechanisms for aBL tolerance development.

引用

页数：16

共 50 条

[31] Mechanisms of antimicrobial resistance in Gram-negative bacilli
Étienne Ruppé
Paul-Louis Woerther
François Barbier
Annals of Intensive Care, 5
[32] Mechanisms of antimicrobial resistance in Gram-negative bacilli
Ruppe, Etienne
Woerther, Paul-Louis
Barbier, Francois
ANNALS OF INTENSIVE CARE, 2015, 5
[33] GRAM-NEGATIVE INFECTIONS - ANTIMICROBIAL RESISTANCE AND PLASMIDS
HAWKEY, PM
CURRENT OPINION IN INFECTIOUS DISEASES, 1988, 1 (05) : 727 - 734
[34] ENDOTOXINS OF GRAM-NEGATIVE BACTERIA AND HOST RESISTANCE
ROSEN, FS
NEW ENGLAND JOURNAL OF MEDICINE, 1961, 264 (18): : 919 - +
[35] ENDOTOXINS OF GRAM-NEGATIVE BACTERIA AND HOST RESISTANCE
ROSEN, FS
NEW ENGLAND JOURNAL OF MEDICINE, 1961, 264 (19): : 980 - +
[36] Imipenem resistance in aerobic Gram-negative bacteria
Modakkas, EM
Sanyal, SC
JOURNAL OF CHEMOTHERAPY, 1998, 10 (02) : 97 - 101
[37] ADAPTIVE DRUG RESISTANCE IN GRAM-NEGATIVE BACTERIA
DEAN, ACR
PROCEEDINGS OF THE ROYAL SOCIETY OF MEDICINE-LONDON, 1971, 64 (05): : 534 - &
[38] MECHANISMS OF QUINOLONE RESISTANCE IN GRAM-NEGATIVE BACTERIA
CULLMANN, W
IMMUNITAT UND INFEKTION, 1990, 18 (03): : 80 - 88
[39] Emergence of polymyxin resistance in Gram-negative bacteria
Olaitan, Abiola Olumuyiwa
Li, Jian
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2016, 48 (06) : 581 - 582
[40] Detection of resistance phenotypes in gram-negative bacteria
Navarro, Ferran
Calvo, Jorge
Canton, Rafael
Fernandez-Cuenca, Felipe
Mirelis, Beatriz
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2011, 29 (07): : 524 - 534

← 1 2 3 4 5 →