Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?

被引：14

作者：

Rapacka-Zdonczyk, Aleksandra ^{[1
]}

Wozniak, Agata ^{[2
,3
]}

Kruszewska, Beata ^{[1
,2
,3
]}

Waleron, Krzysztof ^{[1
]}

Grinholc, Mariusz ^{[2
,3
]}

机构：

[1] Med Univ Gdansk, Fac Pharm, Dept Pharmaceut Microbiol, Hallera 107, PL-80416 Gdansk, Poland

[2] Univ Gdansk, Intercollegiate Fac Biotechnol, Lab Photobiol & Mol Diagnost, Abrahama 58, PL-80307 Gdansk, Poland

[3] Med Univ Gdansk, Abrahama 58, PL-80307 Gdansk, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 21期

关键词：

antimicrobial blue light; resistance; tolerance; Escherichia coli; Klebsiella pneumoniae; Pseudomonas aeruginosa; 405 NM LIGHT; PSEUDOMONAS-AERUGINOSA; STAPHYLOCOCCUS-AUREUS; IN-VITRO; SOLVENT TOLERANCE; ACID TOLERANCE; ERROR-PRONE; EFFLUX; INACTIVATION; PHOTOINACTIVATION;

D O I：

10.3390/ijms222111579

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antimicrobial blue light (aBL) treatment is considered low risk for the development of bacterial resistance and tolerance due to its multitarget mode of action. The aim of the current study was to demonstrate whether tolerance development occurs in Gram-negative bacteria. We evaluated the potential of tolerance/resistance development in Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa and demonstrated that representative Gram-negative bacteria may develop tolerance to aBL. The observed adaption was a stable feature. Assays involving E. coli K-12 tolC-, tolA-, umuD-, and recA-deficient mutants revealed some possible mechanisms for aBL tolerance development.

引用

页数：16

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