Middle cerebral artery occlusion in Wistar and Fischer-344 rats: Functional and morphological assessment of the model

被引:29
|
作者
Herz, RCG
Jonker, M
Verheul, HB
Hillen, B
Versteeg, DHG
deWildt, DJ
机构
[1] UNIV UTRECHT,RUDOLF MAGNUS INST NEUROSCI,DEPT FUNCT ANAT,3584 CG UTRECHT,NETHERLANDS
[2] UNIV UTRECHT,RUDOLF MAGNUS INST NEUROSCI,DEPT NEUROSURG,3584 CG UTRECHT,NETHERLANDS
[3] NATL INST PUBL HLTH & ENVIRONM PROTECT,LAB PHARMACOL & TOXICOL,3720 BA BILTHOVEN,NETHERLANDS
来源
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1996年 / 16卷 / 02期
关键词
cerebral ischemia; Fischer; 344; rat; infarct size; middle cerebral artery; Wistar rat;
D O I
10.1097/00004647-199603000-00015
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cerebral infarction volume after occlusion of a short proximal segment of the middle cerebral artery (MCA) is reported to be different in Wistar compared to Fischer-344 (F344) rats, in both size and variability. Knowledge about the cause of these differences might enable us to explain and perhaps reduce the variation in infarct volume and create a reproducible model of focal cerebral ischemia in the rat. We investigated in Wistar and F344 rats both the effect of occlusion of a long proximal MCA segment on cerebral infarction volume, visualized by magnetic resonance imaging and histology, and the morphology of the major cerebral arteries. Occlusion of a long proximal MCA segment resulted in a striatal and a small cortical infarction in Wistar and a striatal and sizable cortical infarction in F344 rats (as is the case after occlusion of a short proximal MCA segment). In Wistar rats, however, occlusion of a long proximal MCA segment strongly reduced the variability in infarction volume in comparison to occlusion of a small proximal MCA segment. Analysis of the morphology of the major cerebral arteries showed a significantly higher number of proximal side branches of the long proximal MCA segment in Wistar rats than in F344 rats. We conclude that after short-segment proximal MCA occlusion, extreme variability in cerebral infarction volume in Wistar rats compared to F344 rats may be attributable to a significantly greater number of proximal MCA side branches in Wistar rats than F344 rats.
引用
收藏
页码:296 / 302
页数:7
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