Middle cerebral artery occlusion in Wistar and Fischer-344 rats: Functional and morphological assessment of the model

被引:29
|
作者
Herz, RCG
Jonker, M
Verheul, HB
Hillen, B
Versteeg, DHG
deWildt, DJ
机构
[1] UNIV UTRECHT,RUDOLF MAGNUS INST NEUROSCI,DEPT FUNCT ANAT,3584 CG UTRECHT,NETHERLANDS
[2] UNIV UTRECHT,RUDOLF MAGNUS INST NEUROSCI,DEPT NEUROSURG,3584 CG UTRECHT,NETHERLANDS
[3] NATL INST PUBL HLTH & ENVIRONM PROTECT,LAB PHARMACOL & TOXICOL,3720 BA BILTHOVEN,NETHERLANDS
来源
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1996年 / 16卷 / 02期
关键词
cerebral ischemia; Fischer; 344; rat; infarct size; middle cerebral artery; Wistar rat;
D O I
10.1097/00004647-199603000-00015
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cerebral infarction volume after occlusion of a short proximal segment of the middle cerebral artery (MCA) is reported to be different in Wistar compared to Fischer-344 (F344) rats, in both size and variability. Knowledge about the cause of these differences might enable us to explain and perhaps reduce the variation in infarct volume and create a reproducible model of focal cerebral ischemia in the rat. We investigated in Wistar and F344 rats both the effect of occlusion of a long proximal MCA segment on cerebral infarction volume, visualized by magnetic resonance imaging and histology, and the morphology of the major cerebral arteries. Occlusion of a long proximal MCA segment resulted in a striatal and a small cortical infarction in Wistar and a striatal and sizable cortical infarction in F344 rats (as is the case after occlusion of a short proximal MCA segment). In Wistar rats, however, occlusion of a long proximal MCA segment strongly reduced the variability in infarction volume in comparison to occlusion of a small proximal MCA segment. Analysis of the morphology of the major cerebral arteries showed a significantly higher number of proximal side branches of the long proximal MCA segment in Wistar rats than in F344 rats. We conclude that after short-segment proximal MCA occlusion, extreme variability in cerebral infarction volume in Wistar rats compared to F344 rats may be attributable to a significantly greater number of proximal MCA side branches in Wistar rats than F344 rats.
引用
收藏
页码:296 / 302
页数:7
相关论文
共 50 条
  • [21] COLLATERAL DEVELOPMENT AFTER CAROTID-ARTERY OCCLUSION IN FISCHER 344 RATS
    COYLE, P
    PANZENBECK, MJ
    STROKE, 1990, 21 (02) : 316 - 321
  • [22] CEREBRAL OXYGEN-CONSUMPTION AND BLOOD-FLOW IN FISCHER-344 RATS OF DIFFERENT AGES
    BUCHWEITZMILTON, E
    WEISS, HR
    NEUROBIOLOGY OF AGING, 1987, 8 (01) : 55 - 60
  • [23] Functional improvement by electroacupuncture after transient middle cerebral artery occlusion in rats
    Wang, SJ
    Omori, N
    Li, F
    Jin, G
    Hamakawa, Y
    Sato, K
    Nagano, I
    Shoji, M
    Abe, K
    NEUROLOGICAL RESEARCH, 2003, 25 (05) : 516 - 521
  • [25] POLYCHLOROTRIFLUOROETHYLENE (PCTFE) OLIGOMER PHARMACOKINETICS IN FISCHER-344 RATS - DEVELOPMENT OF A PHYSIOLOGICALLY BASED MODEL
    VINEGAR, A
    SECKEL, CS
    POLLARD, DL
    KINKEAD, ER
    CONOLLY, RB
    ANDERSEN, ME
    FUNDAMENTAL AND APPLIED TOXICOLOGY, 1992, 18 (04): : 504 - 514
  • [26] MORPHOLOGICAL AND NEUROCHEMICAL FEATURES OF CULTURED PRIMARY SKIN FIBROBLASTS OF FISCHER-344 RATS FOLLOWING STRIATAL IMPLANTATION
    KAWAJA, MD
    GAGE, FH
    JOURNAL OF COMPARATIVE NEUROLOGY, 1992, 317 (01) : 102 - 116
  • [27] The quantitative assessment of functional impairment and its correlation to infarct volume in rats with transient middle cerebral artery occlusion
    Lim, Seong Hoon
    Lee, Jung Soo
    Lee, Jong In
    Im, Sun
    Ko, Young Jin
    Kim, Hye Won
    BRAIN RESEARCH, 2008, 1230 : 303 - 309
  • [28] FUNCTIONAL ELONGATION OF CA1 HIPPOCAMPAL-NEURONS WITH AGING IN FISCHER-344 RATS
    TURNER, DA
    DEUPREE, DL
    NEUROBIOLOGY OF AGING, 1991, 12 (03) : 201 - 210
  • [29] TRANSIENT MIDDLE CEREBRAL-ARTERY (MCA) OCCLUSION CAUSES SELECTIVE NEURONAL NECROSIS (WISTAR RATS)
    GARCIA, JH
    LIU, KF
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1995, 54 (03): : 461 - 461
  • [30] Citalopram attenuated neurobehavioral, biochemical, and metabolic alterations in transient middle cerebral artery occlusion model of stroke in male Wistar rats
    Gupta, Sangeetha
    Upadhayay, Deepti
    Sharma, Uma
    Jagannathan, Naranamangalam R.
    Gupta, Yogendra Kumar
    JOURNAL OF NEUROSCIENCE RESEARCH, 2018, 96 (07) : 1277 - 1293