Middle cerebral artery occlusion in Wistar and Fischer-344 rats: Functional and morphological assessment of the model

被引:29
|
作者
Herz, RCG
Jonker, M
Verheul, HB
Hillen, B
Versteeg, DHG
deWildt, DJ
机构
[1] UNIV UTRECHT,RUDOLF MAGNUS INST NEUROSCI,DEPT FUNCT ANAT,3584 CG UTRECHT,NETHERLANDS
[2] UNIV UTRECHT,RUDOLF MAGNUS INST NEUROSCI,DEPT NEUROSURG,3584 CG UTRECHT,NETHERLANDS
[3] NATL INST PUBL HLTH & ENVIRONM PROTECT,LAB PHARMACOL & TOXICOL,3720 BA BILTHOVEN,NETHERLANDS
来源
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1996年 / 16卷 / 02期
关键词
cerebral ischemia; Fischer; 344; rat; infarct size; middle cerebral artery; Wistar rat;
D O I
10.1097/00004647-199603000-00015
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cerebral infarction volume after occlusion of a short proximal segment of the middle cerebral artery (MCA) is reported to be different in Wistar compared to Fischer-344 (F344) rats, in both size and variability. Knowledge about the cause of these differences might enable us to explain and perhaps reduce the variation in infarct volume and create a reproducible model of focal cerebral ischemia in the rat. We investigated in Wistar and F344 rats both the effect of occlusion of a long proximal MCA segment on cerebral infarction volume, visualized by magnetic resonance imaging and histology, and the morphology of the major cerebral arteries. Occlusion of a long proximal MCA segment resulted in a striatal and a small cortical infarction in Wistar and a striatal and sizable cortical infarction in F344 rats (as is the case after occlusion of a short proximal MCA segment). In Wistar rats, however, occlusion of a long proximal MCA segment strongly reduced the variability in infarction volume in comparison to occlusion of a small proximal MCA segment. Analysis of the morphology of the major cerebral arteries showed a significantly higher number of proximal side branches of the long proximal MCA segment in Wistar rats than in F344 rats. We conclude that after short-segment proximal MCA occlusion, extreme variability in cerebral infarction volume in Wistar rats compared to F344 rats may be attributable to a significantly greater number of proximal MCA side branches in Wistar rats than F344 rats.
引用
收藏
页码:296 / 302
页数:7
相关论文
共 50 条
  • [31] Sensorimotor impairments in Wistar Kyoto rats with cerebral infarction, induced by unilateral occlusion of the middle cerebral artery: Recovery of function
    vanderStaay, FJ
    Augstein, KH
    Horvath, E
    BRAIN RESEARCH, 1996, 715 (1-2) : 180 - 188
  • [32] Mouse Model of Middle Cerebral Artery Occlusion
    Chiang, Terrance
    Messing, Robert O.
    Chou, Wen-Hai
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2011, (48):
  • [33] CEREBRAL BLOOD-FLOW AND OXIDATIVE-METABOLISM IN CONSCIOUS FISCHER-344 RATS OF DIFFERENT AGES
    TAKEI, H
    FREDERICKS, WR
    LONDON, ED
    RAPOPORT, SI
    JOURNAL OF NEUROCHEMISTRY, 1983, 40 (03) : 801 - 805
  • [34] Permanent endovascular occlusion of the middle cerebral artery in Wistar rats:: A description of surgical approach through the internal carotid artery
    Peña-Tapia, PG
    Díaz, AH
    Torres, JL
    REVISTA DE NEUROLOGIA, 2004, 39 (11) : 1011 - 1016
  • [35] REGIONAL CEREBRAL PALMITATE INCORPORATION AFTER UNILATERAL AUDITORY DEPRIVATION IN IMMATURE AND ADULT FISCHER-344 RATS
    TONE, O
    MILLER, JC
    BELL, JM
    RAPOPORT, SI
    EXPERIMENTAL NEUROLOGY, 1988, 100 (03) : 491 - 505
  • [36] Troxerutin exerts neuroprotection at middle cerebral artery occlusion/reperfusion model in rats
    Duan, Y.
    Ding, Y.
    Wu, D.
    Ji, X.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2019, 39 : 371 - 371
  • [37] Strain Differences in Intraluminal Thread Model of Middle Cerebral Artery Occlusion in Rats
    Svoboda, J.
    Litvinec, A.
    Kala, D.
    Posusta, A.
    Vavrova, L.
    Jiruska, P.
    Otahal, J.
    PHYSIOLOGICAL RESEARCH, 2019, 68 (01) : 37 - 48
  • [38] Transient middle cerebral artery occlusion in rats as an experimental model of brain ischemia
    Calloni, Renato Luis
    Winkler, Bruno Costamilam
    Ricci, Guilherme
    Poletto, Marcos Giacomelli
    Homero, Wagner Martins
    Serafini, Eduardo Pretto
    Corleta, Oly Campos
    ACTA CIRURGICA BRASILEIRA, 2010, 25 (05) : 428 - 433
  • [39] Evaluation of Withania somnifera in a middle cerebral artery occlusion model of stroke in rats
    Chaudhary, G
    Sharma, U
    Jagannathan, NR
    Gupta, YK
    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2003, 30 (5-6) : 399 - 404
  • [40] Endovascular middle cerebral artery occlusion in rats as a model for studying vascular dementia
    Yang, Shao-Hua
    Shetty, Ritu A.
    Liu, Ran
    Sumien, Nathalie
    Heinrich, Kevin R.
    Rutledge, Margaret
    Thangthaeng, Nopporn
    Thangthaeng, Nopporn
    Brun-Zinkernagel, Anne-Marie
    Forster, Michael J.
    AGE, 2006, 28 (03) : 297 - 307