Polyketides with anti-inflammatory activity from Rhodiola tibetica endophytic fungus Alternaria sp. HJT-Y7

被引：4
|
作者：
Tang, Xiaoyuan [1 ]
Zhao, Yuxuan [1 ]
Wang, Xude [2 ]
Ye, Chongtao [2 ]
Feng, Baomin [1 ]
Tang, Chuan [1 ]
Lu, Xuan [1 ]
机构：
[1] Dalian Univ, Coll Life Hlth, Dalian 116622, Peoples R China
[2] Dalian Univ, Coll Med, Dalian 116622, Peoples R China
来源：
PHYTOCHEMISTRY | 2022年 / 203卷
关键词：
Rhodiola tibetica; Crassulaceae; Alternaria sp; HJT-Y7; Pleosporaceae; Polyketide; Anti-inflammatory; Endophyte; METABOLITE; NMR;
D O I：
10.1016/j.phytochem.2022.113383
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Seven undescribed polyketides with particular ortho-trisubstituted benzo[c]furan and benzo[c]oxepin spiro structures were isolated from Rhodiola tibetica endophytic fungus Alternaria sp. HJT-Y7. Structural elucidations of these compounds were determined mainly by NMR and HR-ESI-MS analysis. An assumed polyketide biosynthetic pathway of these isolates was proposed. Two undescribed compounds and four known compounds showed significant inhibitory effects on LPS-induced NO production in RAW 264.7 cells without cytotoxicity at their effective concentrations.
引用
收藏
页数：7
相关论文
共 50 条
  • [41] (±)-Alternamgin, a Pair of Enantiomeric Polyketides, from the Endophytic Fungi Alternaria sp. MG1
    Wu, Jun-Chen
    Hou, Yanan
    Xu, Qianhe
    Jin, Xiao-Jie
    Chen, Yaxiong
    Fang, Jianguo
    Hu, Burong
    Wu, Quan-Xiang
    ORGANIC LETTERS, 2019, 21 (05) : 1551 - 1554
  • [42] Toxic polyketides produced by Fusarium sp., an endophytic fungus isolated from Melia azedarach
    Yang, Sheng-Xiang
    Gao, Jin-Ming
    Zhang, Qiang
    Laatsch, Hartmut
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (06) : 1887 - 1889
  • [43] Diverse anti-inflammation and anti-cancer polyketides isolated from the endophytic fungi Alternaria sp. MG1
    Tian, Li-Li
    Ren, Hao
    Xi, Jun-Min
    Fang, Jianguo
    Zhang, Jin Z.
    Wu, Quan-Xiang
    FITOTERAPIA, 2021, 153
  • [44] Three New Resveratrol Derivatives from the Mangrove Endophytic Fungus Alternaria sp.
    Wang, Jinhua
    Cox, Daniel G.
    Ding, Weijia
    Huang, Guanghao
    Lin, Yongcheng
    Li, Chunyuan
    MARINE DRUGS, 2014, 12 (05): : 2840 - 2850
  • [45] Anti-inflammatory Sesquiterpenoids from a Sponge-Derived Fungus Acremonium sp.
    Zhang, Ping
    Bao, Baoquan
    Dang, Hung The
    Hong, Jongki
    Lee, Hye Ja
    Yoo, Eun Sook
    Bae, Kyung Sook
    Jung, Jee H.
    JOURNAL OF NATURAL PRODUCTS, 2009, 72 (02): : 270 - 275
  • [46] Five Sesquiterpenes from Paraconiothyrium sp. and Their Anti-inflammatory Activity
    Zeng, Qingting
    Cui, Hao
    Yao, Houzong
    Yuan, Tao
    CHEMISTRY & BIODIVERSITY, 2023, 20 (06)
  • [47] Neural anti-inflammatory sesquiterpenoids from the endophytic fungus Trichoderma sp Xy24
    Zhang, Min
    Zhao, Jin-Lian
    Liu, Ji-Mei
    Chen, Ri-Dao
    Xie, Ke-Bo
    Chen, Da-Wei
    Feng, Ke-Ping
    Zhang, Dan
    Dai, Jun-Gui
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2017, 19 (07) : 651 - 658
  • [48] New meroterpenoids and polyketides from the endophytic fungus Paraphaeosphaeria sp. C-XB-J-1 and their anti-inflammatory and SARS-CoV-2 M pro inhibitory activities
    Li, Qi
    Yang, Peng-Yun
    Peng, Chao
    Zhang, Xing-Jie
    Jiang, Yun-Tao
    Li, Yan-Ping
    Gao, Lu
    BIOORGANIC CHEMISTRY, 2024, 147
  • [49] Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, Cytospora sp.
    Wei, Chengwen
    Deng, Qin
    Sun, Mengyu
    Xu, Jing
    MOLECULES, 2020, 25 (18):
  • [50] Polyketides and nitrogenous metabolites from the endophytic fungus Phomopsis sp. D15a2a
    Yu, Haiqian
    Hoefert, Simon-Patrick
    Moussa, Mariam
    Janiak, Christoph
    Mueller, Werner E. G.
    Umeokoli, Blessing O.
    Dai, Haofu
    Liu, Zhen
    Proksch, Peter
    TETRAHEDRON LETTERS, 2019, 60 (51)
12345