Polyketides with anti-inflammatory activity from Rhodiola tibetica endophytic fungus Alternaria sp. HJT-Y7

被引：4

作者：

Tang, Xiaoyuan ^{[1
]}

Zhao, Yuxuan ^{[1
]}

Wang, Xude ^{[2
]}

Ye, Chongtao ^{[2
]}

Feng, Baomin ^{[1
]}

Tang, Chuan ^{[1
]}

Lu, Xuan ^{[1
]}

机构：

[1] Dalian Univ, Coll Life Hlth, Dalian 116622, Peoples R China

[2] Dalian Univ, Coll Med, Dalian 116622, Peoples R China

来源：

PHYTOCHEMISTRY | 2022年 / 203卷

关键词：

Rhodiola tibetica; Crassulaceae; Alternaria sp; HJT-Y7; Pleosporaceae; Polyketide; Anti-inflammatory; Endophyte; METABOLITE; NMR;

D O I：

10.1016/j.phytochem.2022.113383

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven undescribed polyketides with particular ortho-trisubstituted benzo[c]furan and benzo[c]oxepin spiro structures were isolated from Rhodiola tibetica endophytic fungus Alternaria sp. HJT-Y7. Structural elucidations of these compounds were determined mainly by NMR and HR-ESI-MS analysis. An assumed polyketide biosynthetic pathway of these isolates was proposed. Two undescribed compounds and four known compounds showed significant inhibitory effects on LPS-induced NO production in RAW 264.7 cells without cytotoxicity at their effective concentrations.

引用

页数：7

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