Polyketides with anti-inflammatory activity from Rhodiola tibetica endophytic fungus Alternaria sp. HJT-Y7

被引：4
|
作者：
Tang, Xiaoyuan [1 ]
Zhao, Yuxuan [1 ]
Wang, Xude [2 ]
Ye, Chongtao [2 ]
Feng, Baomin [1 ]
Tang, Chuan [1 ]
Lu, Xuan [1 ]
机构：
[1] Dalian Univ, Coll Life Hlth, Dalian 116622, Peoples R China
[2] Dalian Univ, Coll Med, Dalian 116622, Peoples R China
来源：
PHYTOCHEMISTRY | 2022年 / 203卷
关键词：
Rhodiola tibetica; Crassulaceae; Alternaria sp; HJT-Y7; Pleosporaceae; Polyketide; Anti-inflammatory; Endophyte; METABOLITE; NMR;
D O I：
10.1016/j.phytochem.2022.113383
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Seven undescribed polyketides with particular ortho-trisubstituted benzo[c]furan and benzo[c]oxepin spiro structures were isolated from Rhodiola tibetica endophytic fungus Alternaria sp. HJT-Y7. Structural elucidations of these compounds were determined mainly by NMR and HR-ESI-MS analysis. An assumed polyketide biosynthetic pathway of these isolates was proposed. Two undescribed compounds and four known compounds showed significant inhibitory effects on LPS-induced NO production in RAW 264.7 cells without cytotoxicity at their effective concentrations.
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页数：7
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