Advances of immune checkpoints in colorectal cancer treatment

被引：24

作者：

Jiao, Qinlian ^{[1
,2
]}

Ren, Yidan ^{[1
]}

Gabrie, Abakundana Nsenga Ariston ^{[1
]}

Wang, Qin ^{[3
]}

Wang, Yuli ^{[1
]}

Du, Lutao ^{[1
]}

Liu, Xiaoyan ^{[1
]}

Wang, Chuanxin ^{[1
]}

Wang, Yun-shan ^{[1
]}

机构：

[1] Shandong Univ, Dept Clin Lab, Hosp 2, 247 Beiyuan St, Jinan 250033, Shandong, Peoples R China

[2] Shandong Univ Sch Ocean, Int Biotechnol R&D Ctr, 180 Wenhua Xi Rd, Weihai 264209, Shandong, Peoples R China

[3] Shandong Univ, Qilu Hosp, Dept Anesthesiol, 107 Wenhua Xi Rd, Jinan 250012, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2020年 / 123卷

基金：

中国国家自然科学基金;

关键词：

Colorectal cancer; Immunotherapy; Immune checkpoints; T-LYMPHOCYTES; IMMUNOTHERAPY; PD-1; EXPRESSION; PATHWAY; CD28; TIL; COSTIMULATION; CHALLENGES; COMPONENT;

D O I：

10.1016/j.biopha.2019.109745

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Colorectal cancer (CRC) is a malignant gastrointestinal cancer that seriously threatens human health. Its morbidity and mortality are in the forefront of tumors. Chemotherapy and radiotherapy play an important role in the treatment of CRC, which can improve the survival time and quality of life of patients, but the treatment progress is slow, and the treatment effect is not satisfactory. In recent years, immunotherapy has been a new direction in the field of colorectal cancer treatment after radiotherapy, chemotherapy and targeted therapy. Immune checkpoints play a vital role in the immunotherapy of cancer, and take part in the immune escape of cancer, which is closely related to the occurrence and development of cancer. This article reviews the research progress of immune checkpoints and their blockers in the field of CRC, in order to help better use of the immune system to treat cancer.

引用

页数：6

共 50 条

[41] Introduction: Advances in treatment of metastatic colorectal cancer
Folprecht, Gunnar
CANCER TREATMENT REVIEWS, 2008, 34 : S1 - S2
[42] Immune checkpoints and cancer in the immunogenomics era
Park, Ryan
Winnicki, Mary
Liu, Evan
Chu, Wen-Ming
BRIEFINGS IN FUNCTIONAL GENOMICS, 2019, 18 (02) : 133 - 139
[43] Harnessing immune checkpoints for cancer therapy
Vinay, Dass S.
Kwon, Byoung S.
IMMUNOTHERAPY, 2018, 10 (14) : 1265 - 1284
[44] Targeting Immune Checkpoints in Cancer Therapy
Topalian, Suzanne L.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2017, 318 (17): : 1647 - 1648
[45] Emerging immune checkpoints for cancer therapy
Li, Xiaodong
Hu, Wenwei
Zheng, Xiao
Zhang, Chu
Du, Peng
Zheng, Zhuojun
Yang, Yan
Wu, Jun
Ji, Mei
Jiang, Jingting
Wu, Changping
ACTA ONCOLOGICA, 2015, 54 (10) : 1706 - 1713
[46] Molecular advances in the etiology and treatment of colorectal cancer
Bradley, BA
Evers, BM
SURGICAL ONCOLOGY-OXFORD, 1997, 6 (03): : 143 - 156
[47] Advances in the Treatment of Colorectal Cancer Using MicroRNA
Dang, Kai
Gao, Yongguang
Qian, Airong
Dong, Jing
PROCEEDINGS OF 2019 16TH INTERNATIONAL BHURBAN CONFERENCE ON APPLIED SCIENCES AND TECHNOLOGY (IBCAST), 2019, : 309 - 321
[48] ADVANCES IN TREATMENT OF ADVANCED COLORECTAL-CANCER
DIAZRUBIO, E
REVISTA CLINICA ESPANOLA, 1990, 186 (06): : 292 - 300
[49] Recent advances in the pharmacological treatment of colorectal cancer
Messersmith, W
Laheru, D
Hidalgo, M
EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2003, 12 (03) : 423 - 434
[50] Expression of immune checkpoints and T cell exhaustion markers in early and advanced stages of colorectal cancer
Reem Saleh
Rowaida Z. Taha
Salman M. Toor
Varun Sasidharan Nair
Khaled Murshed
Mahwish Khawar
Mahmood Al-Dhaheri
Mahir Abdulla Petkar
Mohamed Abu Nada
Eyad Elkord
Cancer Immunology, Immunotherapy, 2020, 69 : 1989 - 1999

← 1 2 3 4 5 →