Advances of immune checkpoints in colorectal cancer treatment

被引：24
|
作者：
Jiao, Qinlian [1 ,2 ]
Ren, Yidan [1 ]
Gabrie, Abakundana Nsenga Ariston [1 ]
Wang, Qin [3 ]
Wang, Yuli [1 ]
Du, Lutao [1 ]
Liu, Xiaoyan [1 ]
Wang, Chuanxin [1 ]
Wang, Yun-shan [1 ]
机构：
[1] Shandong Univ, Dept Clin Lab, Hosp 2, 247 Beiyuan St, Jinan 250033, Shandong, Peoples R China
[2] Shandong Univ Sch Ocean, Int Biotechnol R&D Ctr, 180 Wenhua Xi Rd, Weihai 264209, Shandong, Peoples R China
[3] Shandong Univ, Qilu Hosp, Dept Anesthesiol, 107 Wenhua Xi Rd, Jinan 250012, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2020年 / 123卷
基金：
中国国家自然科学基金;
关键词：
Colorectal cancer; Immunotherapy; Immune checkpoints; T-LYMPHOCYTES; IMMUNOTHERAPY; PD-1; EXPRESSION; PATHWAY; CD28; TIL; COSTIMULATION; CHALLENGES; COMPONENT;
D O I：
10.1016/j.biopha.2019.109745
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Colorectal cancer (CRC) is a malignant gastrointestinal cancer that seriously threatens human health. Its morbidity and mortality are in the forefront of tumors. Chemotherapy and radiotherapy play an important role in the treatment of CRC, which can improve the survival time and quality of life of patients, but the treatment progress is slow, and the treatment effect is not satisfactory. In recent years, immunotherapy has been a new direction in the field of colorectal cancer treatment after radiotherapy, chemotherapy and targeted therapy. Immune checkpoints play a vital role in the immunotherapy of cancer, and take part in the immune escape of cancer, which is closely related to the occurrence and development of cancer. This article reviews the research progress of immune checkpoints and their blockers in the field of CRC, in order to help better use of the immune system to treat cancer.
引用
收藏
页数：6
相关论文
共 50 条
  • [21] Advances in the Treatment of Metastatic Colorectal Cancer
    Kurkjian, Carla
    Kummar, Shivaani
    DM DISEASE-A-MONTH, 2010, 56 (04): : 187 - 203
  • [22] Checkpoints and beyond - Immunotherapy in colorectal cancer
    Gutting, Tobias
    Burgermeister, Elke
    Haertel, Nicolai
    Ebert, Matthias P.
    SEMINARS IN CANCER BIOLOGY, 2019, 55 : 78 - 89
  • [23] Immune checkpoints in osteosarcoma: Recent advances and therapeutic potential
    Wen, Yang
    Tang, Fan
    Tu, Chongqi
    Hornicek, Francis
    Duan, Zhenfeng
    Min, Li
    CANCER LETTERS, 2022, 547
  • [24] Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer
    Apostolos Zaravinos
    Constantinos Roufas
    Majdi Nagara
    Beatriz de Lucas Moreno
    Maria Oblovatskaya
    Christodoulos Efstathiades
    Christos Dimopoulos
    Georgios D. Ayiomamitis
    Journal of Experimental & Clinical Cancer Research, 38
  • [25] Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer
    Zaravinos, Apostolos
    Roufas, Constantinos
    Nagara, Majdi
    de Lucas Moreno, Beatriz
    Oblovatskaya, Maria
    Efstathiades, Christodoulos
    Dimopoulos, Christos
    Ayiomamitis, Georgios D.
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2019, 38 (01)
  • [26] Exosomes carrying immune checkpoints, a promising therapeutic approach in cancer treatment
    Seyed Ziaeddin Rasihashemi
    Hadi Sahrai
    Erfan Rezazadeh-Gavgani
    Yalda Yazdani
    Amirreza Khalaji
    Parisa Lotfinejad
    Medical Oncology, 39
  • [27] On the Horizon: Targeting Next-Generation Immune Checkpoints for Cancer Treatment
    Tundo, Grazia R.
    Sbardella, Diego
    Lacal, Pedro M.
    Graziani, Grazia
    Marini, Stefano
    CHEMOTHERAPY, 2019, 64 (02) : 62 - 80
  • [28] Exosomes carrying immune checkpoints, a promising therapeutic approach in cancer treatment
    Rasihashemi, Seyed Ziaeddin
    Sahrai, Hadi
    Rezazadeh-Gavgani, Erfan
    Yazdani, Yalda
    Khalaji, Amirreza
    Lotfinejad, Parisa
    MEDICAL ONCOLOGY, 2022, 39 (12)
  • [29] Immune Checkpoints in B Cells: Unlocking New Potentials in Cancer Treatment
    Shi, Xiaoye
    Cheng, Xiangshu
    Jiang, Aimin
    Shi, Wenjie
    Zhu, Lingxuan
    Mou, Weiming
    Glaviano, Antonino
    Liu, Zaoqu
    Cheng, Quan
    Lin, Anqi
    Wang, Linhui
    Luo, Peng
    ADVANCED SCIENCE, 2024, 11 (47)
  • [30] Combining inhibition of immune checkpoints and PARP: rationale and perspectives in cancer treatment
    Catalano, Martina
    Francesco Iannone, Luigi
    Cosso, Federica
    Generali, Daniele
    Mini, Enrico
    Roviello, Giandomenico
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2022, 26 (11) : 923 - 936
12345