Advances of immune checkpoints in colorectal cancer treatment

被引：24
|
作者：
Jiao, Qinlian [1 ,2 ]
Ren, Yidan [1 ]
Gabrie, Abakundana Nsenga Ariston [1 ]
Wang, Qin [3 ]
Wang, Yuli [1 ]
Du, Lutao [1 ]
Liu, Xiaoyan [1 ]
Wang, Chuanxin [1 ]
Wang, Yun-shan [1 ]
机构：
[1] Shandong Univ, Dept Clin Lab, Hosp 2, 247 Beiyuan St, Jinan 250033, Shandong, Peoples R China
[2] Shandong Univ Sch Ocean, Int Biotechnol R&D Ctr, 180 Wenhua Xi Rd, Weihai 264209, Shandong, Peoples R China
[3] Shandong Univ, Qilu Hosp, Dept Anesthesiol, 107 Wenhua Xi Rd, Jinan 250012, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2020年 / 123卷
基金：
中国国家自然科学基金;
关键词：
Colorectal cancer; Immunotherapy; Immune checkpoints; T-LYMPHOCYTES; IMMUNOTHERAPY; PD-1; EXPRESSION; PATHWAY; CD28; TIL; COSTIMULATION; CHALLENGES; COMPONENT;
D O I：
10.1016/j.biopha.2019.109745
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Colorectal cancer (CRC) is a malignant gastrointestinal cancer that seriously threatens human health. Its morbidity and mortality are in the forefront of tumors. Chemotherapy and radiotherapy play an important role in the treatment of CRC, which can improve the survival time and quality of life of patients, but the treatment progress is slow, and the treatment effect is not satisfactory. In recent years, immunotherapy has been a new direction in the field of colorectal cancer treatment after radiotherapy, chemotherapy and targeted therapy. Immune checkpoints play a vital role in the immunotherapy of cancer, and take part in the immune escape of cancer, which is closely related to the occurrence and development of cancer. This article reviews the research progress of immune checkpoints and their blockers in the field of CRC, in order to help better use of the immune system to treat cancer.
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页数：6
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