THE HUMAN SAFE NLRP3 INFLAMMASOME INHIBITOR OLT1177 SUPPRESSES JOINT INFLAMMATION IN MURINE MODELS OF EXPERIMENTAL ARTHRITIS

被引：6
|
作者：
Marchetti, C. [1 ]
Swartzwelter, B. [1 ]
Koenders, I. [2 ]
Dinarello, C. A. [1 ]
Joosten, L. A. [3 ]
机构：
[1] Univ Colorado, Dept Med, Aurora, CO USA
[2] Radboud Univ Nijmegen, Med Ctr, Dept Rheumatol, Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Med Ctr, Dept Med, Nijmegen, Netherlands
来源：
ANNALS OF THE RHEUMATIC DISEASES | 2017年 / 76卷
关键词：
D O I：
10.1136/annrheumdis-2017-eular.2775
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
OP0090
引用
收藏
页码：89 / 89
页数：1
相关论文
共 50 条
  • [1] NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis
    Carlo Marchetti
    Benjamin Swartzwelter
    Marije I. Koenders
    Tania Azam
    Isak W. Tengesdal
    Nick Powers
    Dennis M. de Graaf
    Charles A. Dinarello
    Leo A. B. Joosten
    Arthritis Research & Therapy, 20
  • [2] NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis
    Marchetti, Carlo
    Swartzwelter, Benjamin
    Koenders, Marije I.
    Azam, Tania
    Tengesdal, Isak W.
    Powers, Nick
    de Graaf, Dennis M.
    Dinarello, Charles A.
    Joosten, Leo A. B.
    ARTHRITIS RESEARCH & THERAPY, 2018, 20
  • [3] The NLRP3 inflammasome inhibitor, OLT1177®, ameliorates experimental allergic asthma in mice
    Lunding, Lars P.
    Skouras, Damaris B.
    Vock, Christina
    Dinarello, Charles A.
    Wegmann, Michael
    ALLERGY, 2022, 77 (03) : 1035 - +
  • [4] The NLRP3 Inflammasome Inhibitor OLT1177® Ameliorates Experimental Allergic Asthma in Mice
    Lunding, Lars P.
    Skouras, Damaris B.
    Vock, Christina
    Dinarello, Charles A.
    Wegmann, Michael
    JOURNAL OF IMMUNOLOGY, 2022, 208 (01):
  • [5] NLRP3 Inflammasome Inhibitor OLT1177 Suppresses Onset of Inflammation in Mice with Dextran Sulfate Sodium-Induced Colitis
    Oizumi, Tomofumi
    Mayanagi, Taira
    Toya, Yosuke
    Sugai, Tamotsu
    Matsumoto, Takayuki
    Sobue, Kenji
    DIGESTIVE DISEASES AND SCIENCES, 2022, 67 (07) : 2912 - 2921
  • [6] NLRP3 Inflammasome Inhibitor OLT1177 Suppresses Onset of Inflammation in Mice with Dextran Sulfate Sodium-Induced Colitis
    Tomofumi Oizumi
    Taira Mayanagi
    Yosuke Toya
    Tamotsu Sugai
    Takayuki Matsumoto
    Kenji Sobue
    Digestive Diseases and Sciences, 2022, 67 : 2912 - 2921
  • [7] OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis
    Sanchez-Fernandez, Alba
    Skouras, Damaris B.
    Dinarello, Charles A.
    Lopez-Vales, Ruben
    FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [8] OLT1177, a ß-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation
    Marchetti, Carlo
    Swartzwelter, Benjamin
    Gamboni, Fabia
    Neff, Charles P.
    Richter, Katrin
    Azam, Tania
    Carta, Sonia
    Tengesdal, Isak
    Nemkov, Travis
    D'Alessandro, Angelo
    Henry, Curtis
    Jones, Gerald S.
    Goodrich, Scott A.
    Laurent, Joseph P. St.
    Jones, Terry M.
    Scribner, Curtis L.
    Barrow, Robert B.
    Altman, Roy D.
    Skouras, Damaris B.
    Gattorno, Marco
    Grau, Veronika
    Janciauskiene, Sabina
    Rubartelli, Anna
    Joosten, Leo A. B.
    Dinarello, Charles A.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (07) : E1530 - E1539
  • [9] Treatment with OLT1177™, an Oral NLRP3 Inflammasome Inhibitor, Reduces Systemic Inflammation During Gout Flares in Humans
    Kluck, Viola
    Jansen, Tim
    Janssen, Matthijs
    Tengensdal, Isak
    Schraa, Kiki
    Cleophas, Maartje
    Skouras, Damaris
    Marchetti, Carlo
    Dinarello, Charles
    Joosten, Leo
    ARTHRITIS & RHEUMATOLOGY, 2019, 71
  • [10] OLT1177™, AN ORAL NLRP3 INFLAMMASOME INHIBITOR, INHIBITS ACUTE JOINT INFLAMMATION AND CIRCULATING IL 1β DURING GOUT FLARES IN HUMANS
    Kluck, V.
    Janssen, M.
    Jansen, T. L.
    Tengesdal, I. W.
    Schraa, K.
    Skouras, D. B.
    Marchetti, C.
    Dinarello, C. A.
    Joosten, L. A.
    ANNALS OF THE RHEUMATIC DISEASES, 2019, 78 : A69 - A70
12345