THE HUMAN SAFE NLRP3 INFLAMMASOME INHIBITOR OLT1177 SUPPRESSES JOINT INFLAMMATION IN MURINE MODELS OF EXPERIMENTAL ARTHRITIS

被引:6
|
作者
Marchetti, C. [1 ]
Swartzwelter, B. [1 ]
Koenders, I. [2 ]
Dinarello, C. A. [1 ]
Joosten, L. A. [3 ]
机构
[1] Univ Colorado, Dept Med, Aurora, CO USA
[2] Radboud Univ Nijmegen, Med Ctr, Dept Rheumatol, Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Med Ctr, Dept Med, Nijmegen, Netherlands
关键词
D O I
10.1136/annrheumdis-2017-eular.2775
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OP0090
引用
收藏
页码:89 / 89
页数:1
相关论文
共 50 条
  • [31] Tendril extract of Cucurbita moschata suppresses NLRP3 inflammasome activation in murine macrophages and human trophoblast cells
    Park, Ji-Yeon
    Jo, Sung-Gang
    Lee, Ha-Nul
    Choi, Joo-Hee
    Lee, Yeon-Ji
    Kim, Young-Min
    Cho, Jeong-Yong
    Lee, Sung Ki
    Park, Jong-Hwan
    INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2020, 17 (08): : 1006 - 1014
  • [32] Progesterone Suppresses Neisseria gonorrhoeae-Induced Inflammation Through Inhibition of NLRP3 Inflammasome Pathway in THP-1 Cells and Murine Models
    Zhang, Song
    Zhang, Yingmiao
    Gan, Lu
    Wei, Fen
    Chai, Bao
    Aljaafreh, Amaneh Abdel Hafez
    Liu, Xinxin
    Duan, Xiaoru
    Jiang, Jian
    Wang, Xin
    He, Mengwen
    Huang, Xian
    Cai, Huahua
    Chen, Tie
    Chen, Hongxiang
    FRONTIERS IN MICROBIOLOGY, 2021, 12
  • [33] Preservation of Contractile Reserve and Diastolic Function by Inhibiting the NLRP3 Inflammasome with OLT1177(R) (Dapansutrile) in a Mouse Model of Severe Ischemic Cardiomyopathy Due to Non-Reperfused Anterior Wall Myocardial Infarction
    Aliaga, Joseph
    Bonaventura, Aldo
    Mezzaroma, Eleonora
    Dhakal, Yogesh
    Mauro, Adolfo Gabriele
    Abbate, Antonio
    Toldo, Stefano
    MOLECULES, 2021, 26 (12):
  • [34] Implications of Inflammasomes in Human Diseases: NLRP3 Inflammasome and Animal Models
    Sakimoto, Tohru
    CORNEA, 2018, 37 : S86 - S90
  • [35] Itaconate Suppresses the Activation of Mitochondrial NLRP3 Inflammasome and Oxidative Stress in Allergic Airway Inflammation
    Xie, Qiu-Meng
    Chen, Ning
    Song, Si-Ming
    Zhao, Cui-Cui
    Ruan, Ya
    Sha, Jia-Feng
    Liu, Qian
    Jiang, Xu-Qin
    Fei, Guang-He
    Wu, Hui-Mei
    ANTIOXIDANTS, 2023, 12 (02)
  • [36] Glyburide Suppresses Inflammation-Related Colorectal Tumorigenesis Through Inhibition of NLRP3 Inflammasome
    Maeda, Toshihide
    Shirakami, Yohei
    Taguchi, Daisuke
    Miwa, Takao
    Kubota, Masaya
    Sakai, Hiroyasu
    Ibuka, Takashi
    Mori, Kosuke
    Tomita, Hiroyuki
    Shimizu, Masahito
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (21)
  • [37] Britannin as a novel NLRP3 inhibitor, suppresses inflammasome activation in macrophages and alleviates NLRP3-related diseases in mice
    Shao, Jing-jing
    Li, Wei-feng
    Sun, Jin-feng
    Zhuang, Zai-shou
    Min, Ju-lian
    Long, Xiao-hong
    Wu, Gao-jun
    Xu, Hao-wen
    Liang, Guang
    ACTA PHARMACOLOGICA SINICA, 2024, 45 (04) : 803 - 814
  • [38] Tabersonine, a natural NLRP3 inhibitor, suppresses inflammasome activation in macrophages and attenuate NLRP3-driven diseases in mice
    Xu, Hao-wen
    Li, Wei-feng
    Hong, Shan-shan
    Shao, Jing-jing
    Chen, Jia-hao
    Chattipakorn, Nipon
    Wu, Di
    Luo, Wu
    Liang, Guang
    ACTA PHARMACOLOGICA SINICA, 2023, 44 (06) : 1252 - 1261
  • [39] Tabersonine, a natural NLRP3 inhibitor, suppresses inflammasome activation in macrophages and attenuate NLRP3-driven diseases in mice
    Hao-wen Xu
    Wei-feng Li
    Shan-shan Hong
    Jing-jing Shao
    Jia-hao Chen
    Nipon Chattipakorn
    Di Wu
    Wu Luo
    Guang Liang
    Acta Pharmacologica Sinica, 2023, 44 : 1252 - 1261
  • [40] Britannin as a novel NLRP3 inhibitor, suppresses inflammasome activation in macrophages and alleviates NLRP3-related diseases in mice
    Jing-jing Shao
    Wei-feng Li
    Jin-feng Sun
    Zai-shou Zhuang
    Ju-lian Min
    Xiao-hong Long
    Gao-jun Wu
    Hao-wen Xu
    Guang Liang
    Acta Pharmacologica Sinica, 2024, 45 : 803 - 814