THE HUMAN SAFE NLRP3 INFLAMMASOME INHIBITOR OLT1177 SUPPRESSES JOINT INFLAMMATION IN MURINE MODELS OF EXPERIMENTAL ARTHRITIS

被引：6
|
作者：
Marchetti, C. [1 ]
Swartzwelter, B. [1 ]
Koenders, I. [2 ]
Dinarello, C. A. [1 ]
Joosten, L. A. [3 ]
机构：
[1] Univ Colorado, Dept Med, Aurora, CO USA
[2] Radboud Univ Nijmegen, Med Ctr, Dept Rheumatol, Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Med Ctr, Dept Med, Nijmegen, Netherlands
来源：
ANNALS OF THE RHEUMATIC DISEASES | 2017年 / 76卷
关键词：
D O I：
10.1136/annrheumdis-2017-eular.2775
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
OP0090
引用
收藏
页码：89 / 89
页数：1
相关论文
共 50 条
  • [41] Posttranslational ISGylation of NLRP3 by HERC enzymes facilitates inflammasome activation in models of inflammation
    Qin, Ying
    Meng, Xintong
    Wang, Mengge
    Liang, Wenbo
    Xu, Rong
    Chen, Jingchunyu
    Song, Hui
    Fu, Yue
    Li, Jingxin
    Gao, Chengjiang
    Jia, Mutian
    Zhao, Chunyuan
    Zhao, Wei
    JOURNAL OF CLINICAL INVESTIGATION, 2023, 133 (20):
  • [42] NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice
    Mridha, Auvro R.
    Wree, Alexander
    Robertson, Avril A. B.
    Yeh, Matthew M.
    Johnson, Casey D.
    Van Rooyen, Derrick M.
    Haczeyni, Fahrettin
    Teoh, Narci C. -H.
    Savard, Christopher
    Ioannou, George N.
    Masters, Seth L.
    Schroder, Kate
    Cooper, Matthew A.
    Feldstein, Ariel E.
    Farrell, Geoffrey C.
    JOURNAL OF HEPATOLOGY, 2017, 66 (05) : 1037 - 1046
  • [43] NLRP3 inflammasome activation promotes liver inflammation and fibrosis in experimental biliary atresia
    Wang, Junfeng
    Du, Min
    Meng, Lingdu
    He, Shiwei
    Zhu, Ye
    Yang, Yifan
    Ren, Xue
    Huang, Yanlei
    Sun, Song
    Dong, Rui
    Zheng, Shan
    Chen, Gong
    DIGESTIVE AND LIVER DISEASE, 2024, 56 (03) : 458 - 467
  • [44] Pro-inflammatory role of NLRP3 inflammasome in experimental sterile corneal inflammation
    Hiroaki Shimizu
    Tohru Sakimoto
    Satoru Yamagami
    Scientific Reports, 9
  • [45] The Vitamin E Derivative Garcinoic Acid Suppresses NLRP3 Inflammasome Activation and Pyroptosis in Murine Macrophages
    Boermel, Lisa
    Geisler, Anja R.
    Hupfer, Yvonne
    Liao, Sijia
    Schubert, Tina
    Kluge, Stefan
    Lorkowski, Stefan
    Wallert, Maria
    INFLAMMATION, 2025,
  • [46] Pro-inflammatory role of NLRP3 inflammasome in experimental sterile corneal inflammation
    Shimizu, Hiroaki
    Sakimoto, Tohru
    Yamagami, Satoru
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [47] A Novel Nlrp3 Inflammasome Inhibitor Prevents Acute Pericarditis in an Experimental Mouse Model
    Mauro, Adolfo G.
    Mezzaroma, Eleonora
    Torrado, Juan F.
    Carbone, Salvatore
    Van Tassell, Benjamin W.
    Abbate, Antonio
    Toldo, Stefano
    CIRCULATION, 2016, 134
  • [48] DcR3 suppresses the NF-κB pathway and the NLRP3 inflammasome activation in gouty inflammation
    Jiang, Yi
    Tu, Xin
    Guo, Jianwei
    Zheng, Jianxiong
    Liao, Xia
    He, Yixi
    Xie, Yan
    Zhang, Quanbo
    Qing, Yufeng
    CHINESE MEDICAL JOURNAL, 2024, 137 (21) : 2644 - 2646
  • [49] DcR3 suppresses the NF-κB pathway and the NLRP3 inflammasome activation in gouty inflammation
    Jiang Yi
    Tu Xin
    Guo Jianwei
    Zheng Jianxiong
    Liao Xia
    He Yixi
    Xie Yan
    Zhang Quanbo
    Qing Yufeng
    中华医学杂志英文版, 2024, 137 (21)
  • [50] Curcumin Suppresses IL-1β Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome
    Yin, Haipeng
    Guo, Qiang
    Li, Xin
    Tang, Tiantian
    Li, Cuiling
    Wang, Hengxiao
    Sun, Yuanxin
    Feng, Qi
    Ma, Chunhong
    Gao, Chengjiang
    Yi, Fan
    Peng, Jun
    JOURNAL OF IMMUNOLOGY, 2018, 200 (08): : 2835 - 2846
12345