Flow injection amperometric detection of 2′-deoxyguanosine at a ruthenium oxide hexacyanoferrate modified electrode

被引：22
|
作者：
Paixao, Thiago R. L. C. [1 ]
Garcia, Camila C. M. [1 ]
Medeiros, Marisa H. G. [1 ]
Bertotti, Mauro [1 ]
机构：
[1] Univ Sao Paulo, Inst Quim, BR-05508900 Sao Paulo, SP, Brazil
来源：
ANALYTICAL CHEMISTRY | 2007年 / 79卷 / 14期
关键词：
D O I：
10.1021/ac070490e
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A ruthenium oxide hexacyanoferrate (RuOHCF) modified electrode was developed. Hydrodynamic voltammetry was employed to demonstrate the remarkable electrocatalytic activity toward the oxidation of 2 '-deoxyguanosine. The RuOHCF modified electrode was used as amperometric detector for 2 '-deoxyguanosine determination in a FIA apparatus. The influence of various experimental conditions was explored for optimum analytical performance, and at these experimental conditions, the method exhibited a linear response range to 2 '-deoxyguanosine extending from 3.8 to 252 mu mol L-1 with detection limit of 94 nmol L-1. Applications in DNA samples were examined, and the results for determination of 2 '-deoxyguanosine were in good agreement with those obtained by HPLC analysis. Studies on the kinetics of the in vitro consumption of 2 '-deoxyguanosine by acetaldehyde were also performed.
引用
收藏
页码：5392 / 5398
页数：7
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