(±)-trans-2-[3-methoxy-4-(4-chlorophenyl thioethoxy)-5-cyanophenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent PAF-receptor antagonist

被引：2
|
作者：
Ram, B [1 ]
Balram, B [1 ]
Prakash, PKS [1 ]
机构：
[1] Osmania Univ, Dept Chem, Hyderabad 500007, Andhra Pradesh, India
来源：
TETRAHEDRON | 1999年 / 55卷 / 33期
关键词：
platelet-activating factor; 2,5-transdiaryltetrahydrofuran; acetovanillone;
D O I：
10.1016/S0040-4020(99)00544-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of (+/-)-trans-2-[3-methoxy-4-(chlorophenylthioethoxyphenyl)-5-cyanophenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran from conmercially available acetovanillone and 3,4,5-trimethoxybenzaldehyde is described. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：10163 / 10172
页数：10
相关论文
共 50 条
  • [21] TRANS-2,5-BIS-(3,4,5-TRIMETHOXYPHENYL)TETRAHYDROFURAN - AN ORALLY ACTIVE SPECIFIC AND COMPETITIVE RECEPTOR ANTAGONIST OF PLATELET ACTIVATING FACTOR
    HWANG, SB
    LAM, MH
    BIFTU, T
    BEATTIE, TR
    SHEN, TY
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1985, 260 (29) : 5639 - 5645
  • [22] 3-(4-CHLOROPHENYL)-5-(4-METHOXYPHENYL)ISOXAZOLE
    PERKINS, M
    BEAM, CF
    DYER, MCD
    HAUSER, CR
    ORGANIC SYNTHESES, 1988, 50-9 : 278 - 281
  • [23] 5-Chloro-2-(3,4,5-trimethoxyphenyl)-1,3-benzothiazole
    Yousuf, Sammer
    Shah, Shazia
    Ambreen, Nida
    Khan, Khalid M.
    Ahmad, Shakil
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O3057 - +
  • [24] (E)-3-Allylsulfanyl-N-(4-methoxybenzylidene)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-4-amine
    Li, Qian-Zhu
    Song, Bao-An
    Yang, Song
    Zheng, Yu-Guo
    Guo, Qing-Qing
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O469 - U1339
  • [25] 2-(3-bromo-4-butoxyphenyl)-3,4-dimethyl-5-(3,4,5-trimethoxyphenyl) furan
    Wang, RL
    Shi, JX
    Zheng, XF
    Zhou, Y
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2005, 61 : O2619 - O2620
  • [26] 4,4,5,5-Tetramethyl-2-(3,4,5-trimethoxyphenyl)imidazolidine-1-oxyl 3-oxide
    Wang, Hai-Bo
    Jing, Lin-Lin
    Gao, Peng
    Sun, Xiao-Li
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O2090 - U1450
  • [27] 4-(3-Fluoro-4-methoxyphenyl)-1-(4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-imidazole
    Zhang, Xiao-Meng
    Zhang, Cang
    Zhang, Wen-Ping
    Liu, Xiao-Rong
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O3084 - U2369
  • [28] Ethyl 2-methyl-5-oxo-4-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
    Natarajan, S.
    Indumathi, P.
    Reddy, B. Palakshi
    Vijayakumar, V.
    Lakshman, P. L. Nilantha
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O2240 - U1694
  • [29] Ethyl 2-cyano-5-oxo-5-(thiophen-2-yl)-3(3,4,5-trimethoxyphenyl) pentanoate
    Prabhuswamy, M.
    Kumar, S. Madan
    Raghavendra, K. R.
    Abdoh, M. M. M.
    Shashikanth, S.
    Lokanath, N. K.
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O3275 - +
  • [30] 5-(4-Chlorophenyl)-1-phenylpyrazolidin-3-one
    Shi, H
    Zhu, HJ
    Wang, JT
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2006, 62 : O233 - O235
12345