Beta-carboline alkaloids derived from the ascidian Synoicum sp.

被引：41

作者：

Won, Tae Hyung ^{[2
]}

Jeon, Ju-eun ^{[2
]}

Lee, So-Hyoung ^{[1
]}

Rho, Boon Jo ^{[3
]}

Oh, Ki-Bong ^{[1
]}

Shin, Jongheon ^{[2
]}

机构：

[1] Seoul Natl Univ, Dept Agr Biotechnol, Coll Agr & Life Sci, Seoul 151921, South Korea

[2] Seoul Natl Univ, Coll Pharm, Inst Nat Prod Res, Seoul 151742, South Korea

[3] Ehwa Womans Univ, Coll Life Sci, Dept Biol Sci, Seoul 120750, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2012年 / 20卷 / 13期

基金：

新加坡国家研究基金会;

关键词：

beta-Carboline alkaloids; Eudistomin Y class; Synoicum sp; Chemical modification; Bioactivity; TUNICATE EUDISTOMA-OLIVACEUM; STAPHYLOCOCCUS-AUREUS; CELL-WALL; VIRULENCE; GLAUCUS; DERIVATIVES; INHIBITORS; SORTASE; GROWTH;

D O I：

10.1016/j.bmc.2012.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six beta-carboline alkaloids (1-6) of the eudistomin Y class were isolated from the Korean ascidian Synoicum sp. These compounds were chemically converted to a known compound, eudistomin Y-1 (7) and six new derivatives, designated eudistomins Y-8-Y-13 (8-13). Several of these natural and synthetic compounds exhibited moderate to significant antimicrobial activity, weak cytotoxic activity, and inhibitory activities toward sortase A, isocitrate lyase, and Na+/K+-ATPase. Structure-activity relationships were also deduced. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4082 / 4087

页数：6

共 50 条

[31] THE ALKALOIDS OF PICRASMA-QUASSIOIDES .12. BETA-CARBOLINE ALKALOIDS FROM PICRASMA-QUASSIOIDES
KOIKE, K
OHMOTO, T
IKEDA, K
PHYTOCHEMISTRY, 1990, 29 (09) : 3060 - 3061
[32] Synthesis of didemnolines A-D, N9-substituted β-carboline alkaloids from the marine ascidian Didemnum sp.
Schumacher, RW
Davidson, BS
TETRAHEDRON, 1999, 55 (04) : 935 - 942
[33] CANTHIN-6-ONE AND BETA-CARBOLINE ALKALOIDS FROM AERVA-LANATA
ZAPESOCHNAYA, G
KURKIN, V
OKHANOV, V
MIROSHNIKOV, A
PLANTA MEDICA, 1992, 58 (02) : 192 - 196
[34] NEW CYTOTOXIC BETA-CARBOLINE ALKALOIDS FROM THE MARINE BRYOZOAN, CRIBRICELLINA-CRIBRARIA
PRINSEP, MR
BLUNT, JW
MUNRO, MHG
JOURNAL OF NATURAL PRODUCTS, 1991, 54 (04): : 1068 - 1076
[35] Synoxazolidinones A and B: Novel Bioactive Alkaloids from the Ascidian Synoicum pulmonaria
Tadesse, Margey
Strom, Morten B.
Svenson, Johan
Jaspars, Marcel
Milne, Bruce F.
Torfoss, Veronika
Andersen, Jeanette H.
Hansen, Espen
Stensvag, Klara
Haug, Tor
ORGANIC LETTERS, 2010, 12 (21) : 4752 - 4755
[36] UV MEDIATED CYTO-TOXIC ACTIVITY OF BETA-CARBOLINE ALKALOIDS
MCKENNA, DJ
TOWERS, GHN
PHYTOCHEMISTRY, 1981, 20 (05) : 1001 - 1004
[37] SELENIUM DIOXIDE OXIDATIONS IN THE INDOLE AREA - SYNTHESIS OF BETA-CARBOLINE ALKALOIDS
CAIN, M
CAMPOS, O
GUZMAN, F
COOK, JM
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (04) : 907 - 913
[38] FLUORESCENCE CHARACTERISTICS OF BETA-CARBOLINE ALKALOIDS IN HIGHLY CONCENTRATED HYDROXIDE SOLUTIONS
BALON, M
MUNOZ, MA
HIDALGO, J
CARMONA, MC
SANCHEZ, M
JOURNAL OF PHOTOCHEMISTRY, 1987, 36 (02): : 193 - 204
[39] 8-HYDROXYMANZAMINE-A, A BETA-CARBOLINE ALKALOID FROM A SPONGE, PACHYPELLINA SP
ICHIBA, T
CORGIAT, JM
SCHEUER, PJ
KELLYBORGES, M
JOURNAL OF NATURAL PRODUCTS, 1994, 57 (01): : 168 - 170
[40] A C-13 NMR-STUDY OF BETA-CARBOLINE ALKALOIDS
KOIKE, K
SAKAMOTO, Y
OHMOTO, T
ORGANIC MAGNETIC RESONANCE, 1984, 22 (07): : 471 - 473

← 1 2 3 4 5 →