Beta-carboline alkaloids derived from the ascidian Synoicum sp.

被引：41

作者：

Won, Tae Hyung ^{[2
]}

Jeon, Ju-eun ^{[2
]}

Lee, So-Hyoung ^{[1
]}

Rho, Boon Jo ^{[3
]}

Oh, Ki-Bong ^{[1
]}

Shin, Jongheon ^{[2
]}

机构：

[1] Seoul Natl Univ, Dept Agr Biotechnol, Coll Agr & Life Sci, Seoul 151921, South Korea

[2] Seoul Natl Univ, Coll Pharm, Inst Nat Prod Res, Seoul 151742, South Korea

[3] Ehwa Womans Univ, Coll Life Sci, Dept Biol Sci, Seoul 120750, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2012年 / 20卷 / 13期

基金：

新加坡国家研究基金会;

关键词：

beta-Carboline alkaloids; Eudistomin Y class; Synoicum sp; Chemical modification; Bioactivity; TUNICATE EUDISTOMA-OLIVACEUM; STAPHYLOCOCCUS-AUREUS; CELL-WALL; VIRULENCE; GLAUCUS; DERIVATIVES; INHIBITORS; SORTASE; GROWTH;

D O I：

10.1016/j.bmc.2012.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six beta-carboline alkaloids (1-6) of the eudistomin Y class were isolated from the Korean ascidian Synoicum sp. These compounds were chemically converted to a known compound, eudistomin Y-1 (7) and six new derivatives, designated eudistomins Y-8-Y-13 (8-13). Several of these natural and synthetic compounds exhibited moderate to significant antimicrobial activity, weak cytotoxic activity, and inhibitory activities toward sortase A, isocitrate lyase, and Na+/K+-ATPase. Structure-activity relationships were also deduced. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4082 / 4087

页数：6

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